A Quote by Cynthia Kenyon

With worms you can just change genes at random and see if you can find a mutant that does what you want it to do. — © Cynthia Kenyon
With worms you can just change genes at random and see if you can find a mutant that does what you want it to do.
Epigenetics doesn't change the genetic code, it changes how that's read. Perfectly normal genes can result in cancer or death. Vice-versa, in the right environment, mutant genes won't be expressed. Genes are equivalent to blueprints; epigenetics is the contractor. They change the assembly, the structure.
I agree with O'Toole that custom and comfort are impediments to change. However, it is important to recognize that resistance to change is logical as well. The new "change masters" literature seems to take change as the norm. It isn't. Humans naturally see change as risky because it is risky, just as mutations in genes are mostly destructive. You would not want to go to work were everything changed every week! The phone system, the office assignments, who reports to who, and the whole set of job expectations.
All Satan's Apples Have Worms. I do not deny that the Devil has some pretty apples; I just say that all of them are fakes and that after you bite into them, you will find they have worms. All Satan's apples have worms.
Cheetah genes cooperate with cheetah genes but not with camel genes, and vice versa. This is not because cheetah genes, even in the most poetic sense, see any virtue in the preservation of the cheetah species. They are not working to save the cheetah from extinction like some molecular World Wildlife Fund.
If you want to be happy, make someone else happy. If you want to find the right person in your life, be the right person. If you want to see change in the world, become the change you want to see.
Consider the nematode roundworm, the most abundant of all animals. Four out of five animals on Earth are nematode worms — if all solid materials except nematode worms were to be eliminated, you could still see the ghostly outline of most of it in nematode worms.
It's a very complex network of genes making products which go into the nucleus and turn on other genes. And, in fact, you find a continuing network of processes going on in a very complex way by which genes are subject to these continual adjustments, as you might say - the computer programmer deciding which genes ultimately will work.
Does he or she know you, like you, and trust you? Does he want to see you succeed? Does she want to help you find new business? If so, then you have yourself a 'Personal Walking Ambassador.'
Individuals are not stable things, they are fleeting. Chromosomes too are shuffled into oblivion, like hands of cards soon after they are dealt. But the cards themselves survive the shuffling. The cards are the genes. The genes are not destroyed by crossing-over, they merely change partners and march on. Of course they march on. That is their business. They are the replicators and we are their survival machines. When we have served our purpose we are cast aside. But genes are denizens of geological time: genes are forever.
All the work on heritability was never based on looking at genes; it was based on the similarity between identical twins or between parents and children. Now that geneticists can look at genes, they can't find genes that account for more than 10 percent of the variation in any human trait.
I know if I persist it will pay back in dividends and it always does. What starts to happen is like exercise, the pain goes away. It starts to get easier and the weight starts to get lighter and people start to notice a difference in you and you start to notice a difference in yourself. You find your ability to make decisions is easier; you find you are inspired more often. You find your success increases. You find that your random moments when you're in the flow are no longer random and you can control them. Other people notice the difference.
An Internet meme is a hijacking of the original idea. Instead of mutating by random change and spreading by a form of Darwinian selection, Internet memes are altered deliberately by human creativity. There is no attempt at accuracy of copying, as with genes - and as with memes in their original version.
I'm purposeless. I'm making art because I want you to look at that painting and I want it to affect you in some way, to change what you see, to change how you see it. To change how you see something, whatever.
If you walk up to some random person on the street, grab them by the shoulder, and say 'Did you just see what I saw?!', you'll find that no-one wants to talk to you.
When you're coming into a company and, you know, have to do a transformation, what you really want to do is look at the company and say, 'Okay, here are the parts that the company does well. How do we get those genes to hyper-express? The genes that are getting in the way, how do you turn those off?'
Complex organisms cannot be construed as the sum of their genes, nor do genes alone build particular items of anatomy or behavior by themselves. Most genes influence several aspects of anatomy and behavior as they operate through complex interactions with other genes and their products, and with environmental factors both within and outside the developing organism. We fall into a deep error, not just a harmful oversimplification, when we speak of genes "for" particular items of anatomy or behavior.
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