A Quote by Elizabeth Blackburn
In my lab, we're finding that psychological stress actually ages cells, which can be seen when you measure the wearing down of the tips of the chromosomes, those telomeres.
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Telomeres are the protective caps at the ends of chromosomes in cells. Chromosomes carry the genetic information. Telomeres are buffers. They are like the tips of shoelaces. If you lose the tips, the ends start fraying.
Telomeres are the ends of our chromosomes that control how long we live. As telomeres become shorter, then cells age and die more quickly. In simple terms, as your telomeres get shorter, your life gets shorter.
Exercise mitigates the effects of stress - and stress, we know, shortens telomeres. In fact, early studies indicate that stress reduction techniques like meditation help people maintain the length of their telomeres.
Except for certain moments - when cells are dividing, for instance - chromosomes don't form compact, countable bodies inside cells. Instead, they unravel and flop about, which makes counting chromosomes a bit like counting strands of ramen in a bowl.
It is unlikely that changes in telomeres are influencing the lifespan of the worm. That is because telomeres only shorten when cells divide. Most of the cells of the worm stop dividing when the worm becomes an adult.
Cancer cells have had so many other things go wrong with them, genetic, non-genetic changes, that those cells, one of the things they then get selected for is that they have lots of telomerase because now the telomeres in those cells get maintained.
What I found out on Christmas Day 1984, through biochemical evidence, was that telomeres could be lengthened by the enzyme we called telomerase, which keeps the telomeres from wearing down. After I found that out, I went home and put on Bruce Springsteen's 'Born in the USA,' which was just out, and I danced and danced and danced.
Basically, when you look at different types of cells, such as fibroblasts, which form connective tissue, or epithelial cells, from saliva, you see general correlations within a person. If telomeres are up for one cell type, they're up for others overall.
My lab looks at the ability of stress hormones to kill brain cells, and basically we are trying to understand on a molecular level how a neuron dies after a stroke, a seizure, Alzheimer's, brain aging, and what these stress hormones do to make it worse.
For it is not cell nuclei, not even individual chromosomes, but certain parts of certain chromosomes from certain cells that must be isolated and collected in enormous quantities for analysis; that would be the precondition for placing the chemist in such a position as would allow him to analyse [the hereditary material] more minutely than [can] the morphologists ... For the morphology of the nucleus has reference at the very least to the gearing of the clock, but at best the chemistry of the nucleus refers only to the metal from which the gears are formed.
In 1978, Elizabeth Blackburn, working with Joe Gall, identified the DNA sequence of telomeres. Every time a cell divides, it gets shorter. But telomeres usually don't. So there must be something happening to the telomeres to keep their length in equilibrium.
Brain cells create ideas. Stress kills brain cells. Stress is not a good idea
This enzyme, called telomerase, slows the rate at which telomeres degrade, and research indicates that healthy people with longer telomeres have less risk of developing the common illnesses of aging - like heart disease, diabetes, and cancer, which are three big killers today.
In my lab, we are always thinking about how cells, bacterial cells, can talk to each other and then organize themselves into enormous groups that function in unison.
Chronic emotional stress shortens your telomeres.
When we talk about stem cells, we are actually talking about a complicated series of things, including adult stem cells which are largely cells devoted to replacing individual tissues like blood elements or liver or even the brain.
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