A Quote by Francisco J. Ayala

A hypothesis is empirical or scientific only if it can be tested by experience. A hypothesis or theory which cannot be, at least in principle, falsified by empirical observations and experiments does not belong to the realm of science.
A system is empirical or scientific only if it is capable of being tested by experience. These considerations suggest that not the verifiability but the falsifiability of a system is to be taken as a criterion of demarcation... It must be possible for an empirical or scientific system to be refuted by experience.
When I was younger, I'd get very empirical with myself. "I have a hypothesis about myself. I'll put myself in a situation, see what happens, then I'll draw a conclusion based on the empirical evidence. Hypothesis: I can play basketball." So I'd try. "Conclusion: I cannot play basketball."
To be sure, Darwin's theory of evolution is imperfect. However, the fact that a scientific theory cannot yet render an explanation on every point should not be used as a pretext to thrust an untestable alternative hypothesis grounded in religion into the science classroom or to misrepresent well-established scientific propositions.
Science ignores the spiritual realm because it is not amenable to scientific analysis. As importantly, the predictive success of Newtonian theory, emphasizing the primacy of a physical Universe, made the existence of spirit and God an extraneous hypothesis that offered no explanatory principles needed by science.
The scientific discovery appears first as the hypothesis of an analogy; and science tends to become independent of the hypothesis.
But I should be very sorry if an interpretation founded on a most conjectural scientific hypothesis were to get fastened to the text in Genesis... The rate of change of scientific hypothesis is naturally much more rapid than that of Biblical interpretations, so that if an interpretation is founded on such an hypothesis, it may help to keep the hypothesis above ground long after it ought to be buried and forgotten.
There is a philosophy that says that if something is unobservable -- unobservable in principle -- it is not part of science. If there is no way to falsify or confirm a hypothesis, it belongs to the realm of metaphysical speculation, together with astrology and spiritualism. By that standard, most of the universe has no scientific reality -- it's just a figment of our imaginations.
One finds the truth by making a hypothesis and comparing observations with the hypothesis.
[Coining phrase "null hypothesis"] In relation to any experiment we may speak of this hypothesis as the "null hypothesis," and it should be noted that the null hypothesis is never proved or established, but is possibly disproved, in the course of experimentation. Every experiment may be said to exist only in order to give the facts a chance of disproving the null hypothesis.
The belief that politics can be scientific must inevitably produce tyrannies. Politics cannot be a science, because in politics theory and practice cannot be separated, and the sciences depend upon their separation. Empirical politics must be kept in bounds by democratic institutions, which leave it up to the subjects of the experiment to say whether it shall be tried, and to stop it if they dislike it, because, in politics, there is a distinction, unknown to science, between Truth and Justice.
If complex organisms demand an explanation, so does a complex designer. And it's no solution to raise the theologian's plea that God (or the Intelligent Designer) is simply immune to the normal demands of scientific explanation. To do so would be to shoot yourself in the foot. You cannot have it both ways. Either ID belongs in the science classroom, in which case it must submit to the discipline required of a scientific hypothesis. Or it does not, in which case, get it out of the science classroom and send it back to church, where it belongs.
The first objection to Darwinism is that it is only a guess and was never anything more. It is called a "hypothesis," but the word "hypothesis," though euphonious, dignified and high-sounding, is merely a scientific synonym for the old-fashioned word "guess." If Darwin had advanced his views as a guess they would not have survived for a year, but they have floated for half a century, buoyed up by the inflated word "hypothesis." When it is understood that "hypothesis" means "guess," people will inspect it more carefully before accepting it.
The indispensability argument says (roughly) that if you have ample reason to accept an empirical scientific theory that makes indispensable use of mathematics, and that theory entails that numbers exist, then you have ample reason to accept that numbers exist. The argument affirms the antecedent of this conditional, and concludes that you have ample reason to believe that numbers exist. What is striking about this argument is that it seems to show that the empirical reasons that suffice for accepting a scientific theory also suffice for accepting a metaphysical claim.
Different ‘philosophies’ represent nothing but methods of evaluation, which may lead to empirical mis-evaluation if science and empirical facts are disregarded.
Any physical theory is always provisional, in the sense that it is only a hypothesis: you can never prove it. No matter how many times the results of experiments agree with some theory, you can never be sure that the next time the result will not contradict the theory.
Discerning the merits of competing claims is where the empirical basis of science should play a role. I cannot stress often enough that what science is all about is not proving things to be true but proving them to be false. What fails the test of empirical reality, as determined by observation and experiment, gets thrown out like yesterday's newspaper.
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