A Quote by Gerald Edelman

Hebb place the Law of Effect at the synaptic level by proposing a correlation model of synaptic modification similar to that of Hayek (1952). This work was seminal in providing a basis for many subsequent theoretical studies . .
Since the idea that modification of synaptic function can provide a basis for memory arose shortly after the first anatomical description of the synapse a number of models (Hebb 1949 . . Hayek 1952 . . Kendel 1981) have been proposed in which various cognitive activities are represented by combinations of the firing patterns of individual neurons.
Most theoretical work since the proposals of Hebb (1949) and Hayek (1952) has relied upon particular forms of dependent synaptic rules in which either pre- or postsynaptic change is contingent upon closely occurring events in both neurons taking part in the synapse.
There's that effect that is very physical, very down there at the synaptic level, which really means microscopic cellular level, but also molecular level, because all of those structures are operating on an electrochemical basis and so the changes there are very important.
You could double the number of synaptic connections in a very simple neurocircuit as a result of experience and learning. The reason for that was that long-term memory alters the expression of genes in nerve cells, which is the cause of the growth of new synaptic connections.
Smell is the shortest synaptic leap in the brain to our memory, and I'm amazed that people don't sniff everything.
Long-term memory involves enduring changes that result from the growth of new synaptic connections.
I like the eclipses, the synaptic jumps of short stories. The reader has to participate very actively in the experience.
The first proponent of cortical memory networks on a major scale was neither a neuroscientist nor a computer scientist but .. a Viennes economist: Friedrich von Hayek (1899-1992). A man of exceptionally broad knowledge and profound insight into the operation of complex systems, Hayek applied such insight with remarkable success to economics (Nobel Prize, 1974), sociology, political science, jurisprudence, evolutionary theory, psychology, and brain science (Hayek, 1952).
Synaptic summation is the technical term used in neurophysiology for those instances in which some neuron C is fired only by a combination of neurons A and B.
It seems that the brain has a "small world" architecture - or at least the cortex does. Everything can connect to everything else in a few synaptic steps.
Playful stimulation probably hits all kinds of synaptic possibilities. It is all make-believe and all over the map. The potentiality of the synapses and the potentiality of playfulness are a beautiful marriage.
But Friedman seemed to share Friedrich Hayek's extreme and inaccurate view that socialism of the sort that Britain embraced under the old Labour Party was incompatible with democracy, and I don't think that there is a good theoretical or empirical basis for that view. The Road to Serfdom flunks the test of accuracy of prediction!
Hayek made a quite fruitful suggestion, made contemporaneously by the psychologist Donald Hebb, that whatever kind of encounter the sensory system has with the world, a corresponding event between a particular cell in the brain and some other cell carrying the information from the outside word must result in reinforcement of the connection between those cells. These day, this is known as a Hebbian synapse, but von Hayek quite independently came upon the idea. I think the essence of his analysis still remains with us.
By the way, pornography? It's a new synaptic pathway. You wake up in the morning, open a thumbnail page, and it leads to a Pandora's box of visuals. There have probably been days when I saw 300 vaginas before I got out of bed.
"You were designed to be very smart, Max," she told me. "We electrically stimulated your synaptic nerve endings while your brain was developing." "And yet I still can't program my DVD player," I said.
As the brain matures, one thing that happens is the pruning of the synapses. Synaptic pruning does not occur willy-nilly; it depends largely on how any one brain pathway is used.
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