A Quote by Arthur Kornberg
I feel now, as we did then, that for an effective approach to the problem of nucleic acid biosynthesis, it was essential to understand the biosynthesis of the simple nucleotides and the coenzymes and to have these concepts and methodology well in hand.
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Nucleic acids are the main information-carrying molecules of the cell, and, by directing the process of protein synthesis, they determine the inherited characteristics of every living thing. The two main classes of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA).
It now seems certain that the amino acid sequence of any protein is determined by the sequence of bases in some region of a particular nucleic acid molecule.
At the end of the 1970s, I was a young researcher at the Weizmann Institute with an ambitious plan to shed light on one of the major outstanding questions concerning living cells: the process of protein biosynthesis.
I am not very interested in extraordinary angles. They can be effective on certain occasions, but I do not feel the necessity for them in my own work. Indeed, I feel the simplest approach can often be most effective. A subject placed squarely in the center of the frame, if attention is not distracted from it by fussy surroundings, has a simple dignity which makes it all the more impressive.
All life is nucleic acid; the rest is commentary.
For the problem of decision-making in our complicated world is not how to get the problem simple enough so that we can all understand it; the problem is how to get our thinking about the problem as complex as humanly possible--and thus approach (we can never match) the complexity of the real world around us.
It isn't me making money as much as it is me spending my money in a way that I feel is effective. My methodology is to say I'm not just going to throw money at a problem but rather personally invest myself in it.
Now if you can recognize and memorize a grandmaster's game, and you have the respect to understand [Zimbabwean president Robert] Mugabe who has survived past anyone's expectations, and make the simple assumption it wasn't an accident, and you understand why he did what he did, now you're ready to predict ... The key to forecasting is to understand both the constraints nations are under and the manner in which the struggle for power shapes leaders.
Virus particles contain single molecules of nucleic acid.
We are now witnessing, after the slow fermentation of fifty years, a concentration of technical power aimed at the essential determinants of heredity, development and disease. This concentration is made possible by the common function of nucleic acids as the molecular midwife of all reproductive particles. Indeed it is the nucleic acids which, in spite of their chemical obscurity, are giving to biology a unity which has so far been lacking, a chemical unity.
People don't understand this: Ideas are important, but they're not essential. What's essential and important is the execution of the idea. Everyone has had the experience of seeing a movie and saying, "Hey! That was my idea!" Well, it doesn't mean anything that you had that idea. There's no such thing as an original concept. What's original is the way you re-use ancient concepts.
At first the, only subconsciously apprehended, approaching confluences of complex events make themselves known intuitively within the intellectual weather. Then comes a gradually awakening consciousness of the presence of new families of differentiating-out challenging concepts of every day prominence. It is with these randomly patterning families of separate concepts that evolution is about to deal integratively. As a now specific unitary problem it may be disposed of effectively when and if that unified problem becomes "adequately stated" and thereby comprehensibly solvable.
You are right in demanding that an artist approach his work consciously, but you are confusing two concepts: the solution of a problem and the correct formulation of a problem. Only the second is required of the artist.
From somewhere, back in my youth, heard Prof say, 'Manuel, when faced with a problem you do not understand, do any part of it you do understand, then look at it again.' He had been teaching me something he himself did not understand very well—something in math—but had taught me something far more important, a basic principle.
I don't know about you, but I don't feel that it's my vehicle that is essential. I don't know about you, but I don't feel that it's my education that is essential. I don't think what is essential about me is my house or my car or my clothes. What is essential about me? Well, I think what is essential is that I live and embrace life right now, wherever I am. I grab it in my arms! Don't spend time crying about yesterday-yesterday is over with! I forgive my past. I forgive the people who've hurt me. I don't want to spend the rest of my life blaming and pointing a finger.
The nucleic acids, as constituents of living organisms, are comparable In importance to proteins. There is evidence that they are Involved In the processes of cell division and growth, that they participate In the transmission of hereditary characters, and that they are important constituents of viruses. An understanding of the molecular structure of the nucleic acids should be of value In the effort to understand the fundamental phenomena of life.
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