A Quote by Bonnie Bassler
When antibiotics first came out, nobody could have imagined we'd have the resistance problem we face today. We didn't give bacteria credit for being able to change and adapt so fast.
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Antibiotics are a very serious public health problem for us, and it's getting worse. Resistant microbes outstrip new antibiotics. It's an ongoing problem. It's not like we can fix it, and it's over. We have to fight continued resistance with a continual pipeline of new antibiotics and continue with the perpetual challenge.
Climate change and air pollution know no borders, and antibiotics resistance respects no boundaries. Bacteria from Africa can make people in America sick. The burning of Indonesian forests can keep Asia gasping for breath.
Bacteria evolve, and so they become resistant to existing drugs. Sometimes they revert, depending on how damaging the mutation is to the life cycle of the bacteria. Mutations that give rise to resistance against particular compounds do increase, and that is why you constantly have to have new ones.
Natural selection certainly operates. It explains how bacteria will gain antibiotic resistance; it will explain how insects get insecticide resistance, but it doesn't explain how you get bacteria or insects in the first place.
Take pandemics. There could easily be a severe pandemic. A lot of that comes from something we don't pay much attention to: Eating meat. The meat production industry, the industrial production of meat, uses an immense amount of antibiotics.We're now running out of antibiotics that deal with the threat of rapidly mutating bacteria. A lot of that just comes from the meat production industry. Well, do we worry about it? Well, we ought to be.
I think the easiest application to help people understand what quorum sensing is and why it's important to study is to tell them that if we could make the bacteria either deaf or mute, we could create new antibiotics.
Plants with leaves no more efficient than today's solar cells could out-compete real plants, crowding the biosphere with an inedible foliage. Tough omnivorous bacteria could out-compete real bacteria: They could spread like blowing pollen, replicate swiftly, and reduce the biosphere to dust in a matter of days. Dangerous replicators could easily be too tough, small, and rapidly spreading to stop - at least if we make no preparation. We have trouble enough controlling viruses and fruit flies.
The problem of dealing with the financial industry is being addressed today. You can measure it with interest rates coming down. You can measure it with the quantity of loans, and that sort of thing. The problem is, that nobody wants to take the loans. Once the banks are willing to give it, that's only half the problem.
We've all been sick; we're all afraid of infection. I think the easiest application to help people understand what quorum sensing is and why it's important to study is to tell them that if we could make the bacteria either deaf or mute, we could create new antibiotics.
A man today has to live with the reality of today. He can no longer live with the reality of 100 years ago. The world's changing so fast. Unless you are prepared to adapt every day, then you have a problem, because the world's not stopping.
The successful human being is adaptable. We have to adapt to changes in weather. We have to adapt to changes in climate. We have to adapt to changing economic circumstances. People that don't have the flexibility to adapt or who are afraid of change or who oppose it are going to be left behind.
Anytime we think the problem is 'out there,' that thought is the problem. We empower what's out there to control us. The change paradigm is 'outside-in' - what's out there has to change before we can change. The proactive approach is to change from the 'inside-out': to be different, and by being different, to effect positive change in what's out there - I can be more resourceful, I can be more diligent, I can be more creative, I can be more cooperative.
Because we humans are big and clever enough to produce and utilize antibiotics and disinfectants, it is easy to convince ourselves that we have banished bacteria to the fringes of existence. Don't you believe it. Bacteria may not build cities or have interesting social lives, but they will be here when the Sun explodes. This is their planet, and we are on it only because they allow us to be.
'Star Trek' is the McDonald's of science fiction; it's fast food storytelling. Every problem is like every other problem. They all get solved in an hour. Nobody ever gets hurt, and nobody needs to care. You give up an hour of your time, and you don't really have to get involved. It's all plastic.
Star Trek' is the McDonald's of science fiction; it's fast food storytelling. Every problem is like every other problem. They all get solved in an hour. Nobody ever gets hurt, and nobody needs to care. You give up an hour of your time, and you don't really have to get involved. It's all plastic.
Most organisms either adapt and become part of the system, or get wiped out. The only thing we have to adapt to the system with is our brain. If we don't use it, and we don't adapt fast enough, we won't survive.
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