A Quote by Charles Sanders Peirce

We shall do better to abandon the whole attempt to learn the truthunless we can trust to the human mind's having such a powerof guessing right that before very many hypotheses shall have been tried, intelligent guessing may be expected to lead us to one which will support all tests, leaving the vast majority of possible hypotheses unexamined.
I think equation guessing might be the best method to proceed to obtain the laws for the part of physics which is presently unknown. Yet, when I was much younger, I tried this equation guessing, and I have seen many students try this, but it is very easy to go off in wildly incorrect and impossible directions.
If anyone offers conjectures about the truth of things from the mere possibility of hypotheses, I do not see by what stipulation anything certain can be determined in any science, since one or another set of hypotheses may always be devised which will appear to supply new difficulties.
There are many hypotheses in physics of almost comparable brillance and elegance that have been rejected because they did not survive such a confrontation with experiment. In my view, the human condition would be greatly improved if such confrontations and willingness to reject hypotheses were a regular part of our social, political, economic, religious and cultural lives.
The hypotheses which we accept ought to explain phenomena which we have observed. But they ought to do more than this; our hypotheses ought to foretell phenomena which have not yet been observed; ... because if the rule prevails, it includes all cases; and will determine them all, if we can only calculate its real consequences. Hence it will predict the results of new combinations, as well as explain the appearances which have occurred in old ones. And that it does this with certainty and correctness, is one mode in which the hypothesis is to be verified as right and useful.
Given any rule, however "fundamental" or "necessary" for science, there are always circumstances when it is advisable not only to ignore the rule, but to adopt its opposite. For example, there are circumstances when it is advisable to introduce, elaborate and defend ad hoc hypotheses, or hypotheses which contradict well-established and generally accepted experimental results, or hypotheses whose content is smaller than the content of the existing and empirically adequate alternative, or self-inconsistent hypotheses, and so on.
I think that we shall have to get accustomed to the idea that we must not look upon science as a 'body of knowledge,' but rather as a system of hypotheses; that is to say, as a system of guesses or anticipations which in principle cannot be justified, but with which we work as long as they stand up to tests, and of which we are never justified in saying that we know they are 'true' or 'more or less certain' or even 'probable.'
But these dear boys and girls--there is, something to be made out of them. If now they yield themselves to Christ they may have a long, happy, and holy day before them in which they may serve God with all then hearts. Who knows what glory God may have of them? Heathen lands may call them blessed. Whole nations may be enlightened by them. O brethren and sisters, let us estimate children at their true valuation, and we shall not keep them back, but we shall be eager to lead them to Jesus at once.
Certainly it is permitted to anyone to put forward whatever hypotheses he wishes, and to develop the logical consequences contained in those hypotheses. But in order that this work merit the name of Geometry, it is necessary that these hypotheses or postulates express the result of the more simple and elementary observations of physical figures.
Are not all Hypotheses erroneous, in which Light is supposed to consist in Pression or Motion, propagated through a fluid Medium? For in all these Hypotheses the Phaenomena of Light have been hitherto explain'd by supposing that they arise from new Modifications of the Rays; which is an erroneous Supposition.
The growth of our knowledge is the result of a process closely resembling what Darwin called 'natural selection'; that is, the natural selection of hypotheses: our knowledge consists, at every moment, of those hypotheses which have shown their (comparative) fitness by surviving so far in their struggle for existence, a competitive struggle which eliminates those hypotheses which are unfit.
I shall often go wrong through defect of judgment. When right, I shall often be thought wrong by those whose positions will not command a view of the whole ground. I ask your indulgence for my own errors, which will never be intentional, and your support against the errors of others, who may condemn what they would not if seen in all its parts.
There is no effective difference between guessing a variable that is not random, but for which information is partial or deficient, and a random one. In this sense, guessing (what I don't know, but what someone else may know) and predicting (what has not taken place yet) are the same thing.
My boy, you shall be everything in the world, animal, vegetable, mineral, protista, or virus, for all I care-before I have done with you-but you will have to trust my superior backsight. The time is not yet ripe for you to be a hawk... so you may as well sit down for the moment and learn to be a human being.
My Design in this Book is not to explain the Properties of Light by Hypotheses, but to propose and prove them by Reason and Experiments: In order to which, I shall premise the following Definitions and Axioms.
The time to guard against corruption and tyranny is before they shall have gotten hold of us. It is better to keep the wolf out of the fold, than to trust to drawing his teeth and talons after he shall have entered.
So long as men shall be on earth, there will be tasks for them to do. Some way for them to show their worth. Each day shall bring its problems new. And men shall dream of mightier deeds than ever have been done before. There always shall be human needs for men to work and struggle for.
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