A Quote by Daniel Nathans

First of all, many human diseases are influenced by, if not caused by mutations in genes. — © Daniel Nathans
First of all, many human diseases are influenced by, if not caused by mutations in genes.
We know cancer is caused ultimately via a link between the environment and genes. There are genes inside cells that tell cells to grow and the same genes tell cells to stop growing. When you deregulate these genes, you unleash cancer. Now, what disrupts these genes? Mutations.
Our experience in fooling around with the genes of mice has taught us that many of the traits that interest us are not definite products of specific mutations but emergent phenomena arising from extremely complex interactions between genes, environment, and life experience.
Mutations can arise anywhere in the genome, in gene DNA and noncoding DNA alike. But mutations to genes have bigger consequences: They can disable proteins and kill a creature.
Many people assume the diseases that kill us are pre-programmed into our genes. High blood pressure by 55, heart attacks at 60, maybe cancer at 70, and so on... But for most of the leading causes of death, our genes usually account for only 10-20 per cent of risk.
In the past, geneticists have looked at so-called disease genes, but a lot of people have changes in their genes and don't get these diseases. There have to be other parts of physiology and genetics that compensate.
Many families would like to avoid burdening future generations with inherited diseases such as haemophilia or severe developmental disorders. But most would think it wrong to edit the genes that influence the 'normal' range of human variation, from eye colour to intelligence or athletic ability.
There's already a lot of active research going on using the Crispr technology to fix diseases like Duchenne muscular dystrophy or cystic fibrosis or Huntington's disease. They're all diseases that have known genetic causes, and we now have the technology that can repair those mutations to provide, we hope, patients with a normal life.
A person's health isn't generally a reflection of genes, but how their environment is influencing them. Genes are the direct cause of less than 1pc of diseases: 99pc is how we respond to the world.
All human beings are, in fact, born with dozens of mutations their parents lacked, and a few of those mutations could well be lethal if we didn't have two copies of every gene, so one can pick up the slack if the other malfunctions.
We've just done a five-day retreat at the Chopra centre and people who went to the meditation retreat saw their anti-ageing enzyme increase by 40 per cent. We looked at their 23,000 genes and the self-healing genes were up regulated and all the genes related to heart disease, cancer and inflammatory diseases, diabetes, they all went down within five days.
People need to realize that their thoughts are more primary than their genes, because the environment, which is influenced by our thoughts, controls the genes.
Sexually-transmitted diseases is caused by sexual activity and promiscuity it spreads diseases. That's been known, you know, about 400 or 500 years, that somehow these diseases are spread. If fault comes with people because of their personal behavior but it isn't to be placed on a burden on other people, innocent people, why should they have to pay for the consequences?
Think of all the human suffering caused by the sad truth that beautiful sexy women or handsome Porsche-owning men often prove to have miserable genes for other traits
After observing mutations in fruit flies for many years, Professes Goldschmidt fell into despair. The changes, he lamented, were so hopelessly micro [insignificant] that if a thousand mutations were combined in one specimen, there would still be no new species.
Although random mutations influenced the course of evolution, their influence was mainly by loss, alteration, and refinement... Never, however, did that one mutation make a wing, a fruit, a woody stem, or a claw appear. Mutations, in summary, tend to induce sickness, death, or deficiencies. No evidence in the vast literature of heredity changes shows unambiguous evidence that random mutation itself, even with geographical isolation of populations, leads to speciation.
In our evolutionary narratives, the organism itself often seems to play a passive role: a powerless victim, almost, of changes to its environment or mutations in its genes.
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