A Quote by David Andrew Sinclair
Well, originally we found resveratrol just in a test tube, looking for molecules that would turn on this enzyme, this protein that seems to defend against diseases in aging.
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Resveratrol does not act primarily as an antioxidant. It is far more interesting and powerful than that. Resveratrol turns on our body's genetic defenses against diseases and aging itself.
In order for life to have appeared spontaneously on Earth, there first had to be hundreds of millions of protein molecules of the Ninth Configuration. But, given the size of the planet Earth, do you know how long it would take for just one of these protein molecules to appear by chance? Roughly 10 to the 243rd power, billions of years; and I find that far, far more fantastic than simply believing in a god.
Resveratrol had a decent benefit when the mice were obese and sedentary. The mice that were fed a lean diet and resveratrol lived significantly longer than other treated mice as well as those that had no healthy diet and no resveratrol. So resveratrol is not an excuse to be lazy or eat whatever you want.
In the test tube, I can make any DNA I want, recombining it from monkeys, worms, anywhere. So I can explore new rules of breeding with molecules.
The ultimate goal is to have a pill that can prevent or reverse all diseases of aging. The major diseases that I'd like to tackle are heart disease, diabetes, Alzheimer's and cancer. I want to reduce those diseases by 10 percent.
We knew that all the protein-coding bits of genes do is to produce protein - they have to have instructions to turn them on and off. Those sequences lie well outside the protein-coding sequences, sometimes thousands, tens of thousands of bases away.
I watched Baeyer activating magnesium with iodine for a difficult Grignard reaction; it was done in a test tube, which he watched carefully as he moved it gently by hand over a flame for three quarters of an hour. The test tube was the apparatus to Baeyer.
Protein bars, protein flapjacks, protein granola, protein ice cream and protein coconut water... To look at the health-food aisles, you'd think that protein was a substance no one could overeat. Even bread now comes in protein-enriched form.
Most people believe that aging is painful and we know that pain is from diseases that are preventable, not from aging.
Insulin resistance is the basis of all of the chronic diseases of aging, because the disease itself is actually aging.
The deviation of man from the state in which he was originally placed by nature seems to have proved to him a prolific source of diseases.
The deviation of man from the state in which he was originally placed by nature seems to have proved to him a prolific source of diseases
I tell my students to try to know molecules, so well that when they have some question involving molecules, they can ask themselves, What would I do if I were that molecule?
A scenario is, everyone takes gene therapy - not just curing rare diseases like cystic fibrosis, but diseases that everyone has, like aging.
I juice a lot; I get as much protein as I can, because being a vegan, there isn't much protein. But that's pretty much it. I just drink lots of water, too. I'll have a protein shake as well every morning.
The truth is, the notion that gay marriage is harmful to marriage, is sort of mind-boggling, because these are people trying to get married. But it seems to me, if you want to defend marriage against something, defend it against divorce.
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