A Quote by David Andrew Sinclair
When I started in the field, aging research was the backwater of biology. The idea that you could find a molecule that would prevent many diseases at once was considered impossible.
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The ultimate goal is to have a pill that can prevent or reverse all diseases of aging. The major diseases that I'd like to tackle are heart disease, diabetes, Alzheimer's and cancer. I want to reduce those diseases by 10 percent.
Aging is not currently regarded as a disease, but researchers tend increasingly to view it as the common origin of conditions like insulin resistance or cardiovascular disease, whose incidence rises with age. In treating cell aging, we could prevent these diseases.
Like many great ideas in biology, the idea implicating infectious causation in chronic diseases, though simple, has far-reaching implications. It is so simple and so significant, that one would think it would have been recognized by many and would be the starting point for any discussion on the causes of disease. Not yet.
For example, in Vitamin K, the clotting proteins get it first... and
only after they're satisfied do you prevent calcification of the arteries,
or prevent cancer, or prevent bone fractures. It's all insidious damage
that you get that's a long term consequence. In fact, we call these the
diseases of aging.
I started taking a basic biology course, and I really loved it. I started asking research questions incessantly. I was drawn very quickly to biology.
If you say 'anti-aging,' how anti would it have to be, really? My guess is not much. Any amount of sunscreen could be considered anti-aging.
If my dramatic career doesn't work out, I will go on to research and find cures for Alzheimer's or Parkinson's and other motor neuron diseases. It's a very exciting field of research. But I'd like to continue in drama, so it wouldn't be very smart of me if I blew this amazing opportunity with an inappropriate lifestyle.
In the past, biology has been a backwater type of activity - a bunch of nerds in a lab. Now the sheer potential of biology to re-program our physical world is a new reality for everyone.
Countless people, suffering from many different diseases, stand to benefit from the answers stem cell research can provide. We owe it to ourselves and to our children to do everything in our power to find cures for these diseases - and soon. As I've said before, time is short, and life is precious.
An investigator starts research in a new field with faith, a foggy idea, and a few wild experiments. Eventually the interplay of negative and positive results guides the work. By the time the research is completed, he or she knows how it should have been started and conducted.
In 2007 and 2008, the first two Danish ships were hijacked. I started to research it. I've had the idea of writing in this arena for a long time, but I could never find the angle of what kind of story.
I started working on ribosomes when I was a post doc, in 1978, when it would have been impossible, really, to solve it. But, it was just a fundamental problem in biology.
Most people believe that aging is painful and we know that pain is from diseases that are preventable, not from aging.
Insulin resistance is the basis of all of the chronic diseases of aging, because the disease itself is actually aging.
It is now widely realized that nearly all the 'classical' problems of molecular biology have either been solved or will be solved in the next decade. The entry of large numbers of American and other biochemists into the field will ensure that all the chemical details of replication and transcription will be elucidated. Because of this, I have long felt that the future of molecular biology lies in the extension of research to other fields of biology, notably development and the nervous system.
If it is impossible to judge merit and guilt in the field of natural science, then it is not possible in any field, and historical research becomes an idle, empty activity.
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