A Quote by Enrico Fermi

There's two possible outcomes: if the result confirms the hypothesis, then you've made a discovery. If the result is contrary to the hypothesis, then you've made a discovery.
There are two possible outcomes: if the result confirms the hypothesis, then you've made a measurement. If the result is contrary to the hypothesis, then you've made a discovery.
The scientific discovery appears first as the hypothesis of an analogy; and science tends to become independent of the hypothesis.
However the machine would permit us to test the hypothesis for any special value of n. We could carry out such tests for a sequence of consecutive values n=2,3,.. up to, say, n=100. If the result of at least one test were negative, the hypothesis would prove to be false; otherwise our confidence in the hypothesis would increase, and we should feel encouraged to attempt establishing the hypothesis, instead of trying to construct a counterexample.
It is possible that a scientific discovery will be made that humans will later regret because it has awful consequences. The problem is, we probably would not know in advance and, once the discovery is made, it cannot be undiscovered.
Then he is a monster!" the Prince crowed, "and I must slay him at once. The Formula works!" "Your Formula must result in a great deal of fighting," I mused. "Oh, yes, when applied correctly mighty and noble battles result! Of course I always win—the value of Prince X is a constant. It cannot be lesser than that of Monster Y—this is the Moral Superiority Hypothesis made famous five hundred years ago by my ancestor Ethelred, the Mathematician-King. We have never seen his equal, in all these centuries.
[Coining phrase "null hypothesis"] In relation to any experiment we may speak of this hypothesis as the "null hypothesis," and it should be noted that the null hypothesis is never proved or established, but is possibly disproved, in the course of experimentation. Every experiment may be said to exist only in order to give the facts a chance of disproving the null hypothesis.
Discovery comes as a result of positive discontent, a constructive dissatisfaction. In fact, one might quite truthfully say that there is no discovery when one is content.
A scientific discovery is also a religious discovery. There is no conflict between science and religion. Our knowledge of God is made larger with every discovery we make about the world.
... the mind must be prepared for knowledge as one prepares a field for planting, and a discovery made too soon is no better than a discovery not made at all.
In the discovery of lemmas the best aid is a mental aptitude for it. For we may see many who are quick at solutions and yet do not work by method ; thus Cratistus in our time was able to obtain the required result from first principles, and those the fewest possible, but it was his natural gift which helped him to the discovery.
It appears, then, to be a condition of a genuinely scientific hypothesis, that it be not destined always to remain an hypothesis, but be certain to be either proved or disproved by.. .comparison with observed facts.
If we consistently act on the optimistic hypothesis, this hypothesis will tend to be realised; whilst by acting on the pessimistic hypothesis we can keep ourselves for ever in the pit of want.
Mr. Darwin's hypothesis is not, so far as I am aware, inconsistent with any known biological fact; on the contrary, if admitted, the facts of Development, of Comparative Anatomy, of Geographical Distribution, and of Palaeontology, become connected together, and exhibit a meaning such as they never possessed before; and I, for one, am fully convinced that if not precisely true, that hypothesis is as near an approximation to the truth as, for example, the Copernican hypothesis was to the true theory of the planetary motions.
If the facts are contrary to any predictions, then the hypothesis is wrong no matter how appealing.
But I should be very sorry if an interpretation founded on a most conjectural scientific hypothesis were to get fastened to the text in Genesis... The rate of change of scientific hypothesis is naturally much more rapid than that of Biblical interpretations, so that if an interpretation is founded on such an hypothesis, it may help to keep the hypothesis above ground long after it ought to be buried and forgotten.
Therefore, a grotesque account of a period some thousands of years ago is taken seriously though it be built by piling special assumptions on special assumptions, ad hoc hypothesis [invented for a purpose] on ad hoc hypothesis, and tearing apart the fabric of science whenever it appears convenient. The result is a fantasia which is neither history nor science.
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