A Quote by Francis Crick

The balance of evidence both from the cell-free system and from the study of mutation, suggests that this does not occur at random, and that triplets coding the same amino acid may well be rather similar.

Francis Crick

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Acid Amino Amino Acid Balance Both Cell Coding Does Evidence Free May Mutation Occur Random Rather Same Similar Study System Triplets Well

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Francis Crick
English - Scientist
June 8, 1916 - July 28, 2004

It now seems very likely that many of the 64 triplets, possibly most of them, may code one amino acid or another, and that in general several distinct triplets may code one amino acid.

Francis Crick

The meaning of this observation is unclear, but it raises the unfortunate possibility of ambiguous triplets; that is, triplets which may code more than one amino acid. However one would certainly expect such triplets to be in a minority.

Francis Crick

A comparison between the triplets tentatively deduced by these methods with the changes in amino acid sequence produced by mutation shows a fair measure of agreement.

Francis Crick

That the primary effect of gene mutation may be as simple as the substitution of a single amino acid by another and may lead to profound secondary changes in protein structure and properties has recently been strongly indicated by the work of Ingram on hemoglobin.

Edward Lawrie Tatum

Attempts have been made from a study of the changes produced by mutation to obtain the relative order of the bases within various triplets, but my own view is that these are premature until there is more extensive and more reliable data on the composition of the triplets.

Francis Crick

Although random mutations influenced the course of evolution, their influence was mainly by loss, alteration, and refinement... Never, however, did that one mutation make a wing, a fruit, a woody stem, or a claw appear. Mutations, in summary, tend to induce sickness, death, or deficiencies. No evidence in the vast literature of heredity changes shows unambiguous evidence that random mutation itself, even with geographical isolation of populations, leads to speciation.

Lynn Margulis

Unfortunately it makes the unambiguous determination of triplets by these methods much more difficult than would be the case if there were only one triplet for each amino acid.

Francis Crick

It may act as an ancillary factor, but by itself, the mutation in tau doesn't give you Alzheimer's disease. This is not to say the tau is not very important. It may be important in propagating the disorder from one cell to another. But as a causal mechanism, the evidence is strongest for beta amyloid abnormalities.

Eric Kandel

The study of the amino acid sequence around the disulphide bonds of the immunoglobulins was my own short-cut to the understanding of antibody diversity.

Cesar Milstein

One amino acid does not a protein make-let alone a being.

Preston Cloud

The best scientific evidence suggests temperatures are rising, and the best scientific evidence suggests man-made anthropogenic carbon emissions have some substantial thing to do with that. However, does that mean the trend will continue forever? We don't know.

Bret Stephens

It now seems certain that the amino acid sequence of any protein is determined by the sequence of bases in some region of a particular nucleic acid molecule.

Francis Crick

This seems highly likely, especially as it has been shown that in several systems mutations affecting the same amino acid are extremely near together on the genetic map.

Francis Crick

Mutation is random; natural selection is the very opposite of random.

Richard Dawkins

Evolutionary theory, properly understood, does not conflict with the idea that God occasionally intervenes in nature - for example, by once or twice causing a beneficial mutation to occur. Biologists have not detected any such interventions despite the data and theory they have assembled about mutation. However, I think it is a mistake to expect biological experiments to be able to detect such one-off acts of divine intervention, especially if those acts occurred in the distant past. Science isn't in that line of work.

Elliott Sober

People crave laughter as if it were an essential amino acid.

Patch Adams

A Quote by Francis Crick

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