A Quote by Francois Jacob

Contrary to what I once thought, scientific progress did not consist simply in observing, in accurately formulating experimental facts and drawing up a theory from them. It began with the invention of a possible world, or a fragment thereof, which was then compared by experimentation with the real world. And it was this constant dialogue between imagination and experiment that allowed one to form an increasingly fine-grained conception of what is called reality.
Philosophers of science constantly discuss theories and representation of reality, but say almost nothing about experiment, technology, or the use of knowledge to alter the world. This is odd, because 'experimental method' used to be just another name for scientific method.... I hope [to] initiate a Back-to-Bacon movement, in which we attend more seriously to experimental science. Experimentation has a life of its own.
During all those years of experimentation and research, I never once made a discovery. All my work was deductive, and the results I achieved were those of invention, pure and simple. I would construct a theory and work on its lines until I found it was untenable. Then it would be discarded at once and another theory evolved. This was the only possible way for me to work out the problem.
The scientific theorist is not to be envied. For Nature, or more precisely experiment, is an exorable and not very friendly judge of his work. It never says "yes" to a theory. In the most favorable cases it says "Maybe," and in the great majority of cases simply "No." If an experiment agrees with a theory it means for the latter "Maybe," and if it does not agree it means "No." Probably every theory will some day experience its "No" - most theories, soon after conception.
vivisection is not the same thing as scientific progress. There is such a thing as scientific progress. But this wholesale dedication of scientists to vivisection, which is the easy and cheap way, actually prevents them from scientific progress, for true progress is difficult and requires genius and imagination in its devoted workers.
The progress of Science consists in observing interconnections and in showing with a patient ingenuity that the events of this ever-shifting world are but examples of a few general relations, called laws. To see what is general in what is particular, and what is permanent in what is transitory, is the aim of scientific thought.
Well, it [evolution] is a theory, it is a scientific theory only, and it has in recent years been challenged in the world of science and is not yet believed in the scientific community to be as infallible as it once was believed. But if it was going to be taught in the schools, then I think that also the biblical theory of creation, which is not a theory but the biblical story of creation, should also be taught.
It is possible to express the laws of thermodynamics in the form of independent principles , deduced by induction from the facts of observation and experiment, without reference to any hypothesis as to the occult molecular operations with which the sensible phenomena may be conceived to be connected; and that course will be followed in the body of the present treatise. But, in giving a brief historical sketch of the progress of thermodynamics, the progress of the hypothesis of thermic molecular motions cannot be wholly separated from that of the purely inductive theory.
In the field one has to face a chaos of facts, some of which are so small that they seem insignificant; others loom so large that they are hard to encompass with one synthetic glance. But in this crude form they are not scientific facts at all; they are absolutely elusive, and can be fixed only by interpretation, by seeing them sub specie aeternitatis, by grasping what is essential in them and fixing this. Only laws and generalizations are scientific facts, and field work consists only and exclusively in the interpretation of the chaotic social reality, in subordinating it to general rules.
To draw does not simply mean to reproduce contours; the drawing does not simply consist in the idea: the drawing is even the expression, the interior form, the plan, the model. Look what remains after that! The drawing is three fourths and a half of what constitutes painting. If I had to put a sign over my door to the atelier, I would write: School of drawing, and I'm certain that I would create painters.
There are two ways of forming an opinion. One is the scientific method; the other, the scholastic. To the scientific mind, experimental proof is all-important, and theory is merely a convenience in description, to be junked when it no longer fits. To the academic mind, authority is everything, and facts are junked when they do not fit theory.
The power of the creative imagination is not only merely content with observing the world as it is, accepting a given reality, but is capable of creating a new reality by transforming the inner as well as the outer world
The experimental investigation by which Ampere established the law of the mechanical action between electric currents is one of the most brilliant achievements in science. The whole, theory and experiment, seems as if it had leaped, full grown and full armed, from the brain of the 'Newton of Electricity'. It is perfect in form, and unassailable in accuracy, and it is summed up in a formula from which all the phenomena may be deduced, and which must always remain the cardinal formula of electro-dynamics.
Drawing is the probity of art. To draw does not mean simply to reproduce contours; drawing does not consist merely of line: drawing is also expression, the inner form, the plane, the modeling. See what remains after that.
No theory ever agrees with all the facts in its domain, yet it is not always the theory that is to blame. Facts are constituted by older ideologies, and a clash between facts and theories may be proof of progress. It is also a first step in our attempt to find the principles implicit in familiar observational notions.
A dialogue is very important. It is a form of communication in which question and answer continue till a question is left without an answer. Thus the question is suspended between the two persons involved in this answer and question. It is like a bud with untouched blossoms . . . If the question is left totally untouched by thought, it then has its own answer because the questioner and answerer, as persons, have disappeared. This is a form of dialogue in which investigation reaches a certain point of intensity and depth, which then has a quality that thought can never reach.
There is the theory that all the living forms in the world have arisen from a single source which itself came from an inorganic form. This theory can be called the 'general theory of evolution,' and the evidence which supports this is not sufficiently strong to allow us to consider it as anything more than a working hypothesis.
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