Some molecules - ammonia, carbon dioxide, water - show up everywhere in the universe, whether life is present or not. But others pop up especially in the presence of life itself. Among the biomarkers in Earth's atmosphere are ozone-destroying chlorofluorocarbons from aerosol sprays, vapor from mineral solvents, escaped coolants from refrigerators and air conditioners, and smog from the burning of fossil fuels. No other way to read that list: sure signs of the absence of intelligence.