A Quote by Gary Wolf
Our experience in fooling around with the genes of mice has taught us that many of the traits that interest us are not definite products of specific mutations but emergent phenomena arising from extremely complex interactions between genes, environment, and life experience.
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We know cancer is caused ultimately via a link between the environment and genes. There are genes inside cells that tell cells to grow and the same genes tell cells to stop growing. When you deregulate these genes, you unleash cancer. Now, what disrupts these genes? Mutations.
Complex organisms cannot be construed as the sum of their genes, nor do genes alone build particular items of anatomy or behavior by themselves. Most genes influence several aspects of anatomy and behavior as they operate through complex interactions with other genes and their products, and with environmental factors both within and outside the developing organism. We fall into a deep error, not just a harmful oversimplification, when we speak of genes "for" particular items of anatomy or behavior.
There's this very interesting and complicated connection between our environment and our genes and the traits that come out of the environment plus genes. And there's huge potential. I mean we see amazing abilities. Marie Curie, Albert Einstein. All sorts of arts, and literature and so forth. These are not typical traits of everybody on earth.
It's a very complex network of genes making products which go into the nucleus and turn on other genes. And, in fact, you find a continuing network of processes going on in a very complex way by which genes are subject to these continual adjustments, as you might say - the computer programmer deciding which genes ultimately will work.
Genes are not simple triggers. No one is hardwired to commit murder or any other crime. Our actions are always the result of stupendously complex gene-environment interactions, and environment is likely to remain the more important influence by far.
Isn't it true that whatever isn't determined by our genes must be determined by our environment? What else is there? There's Nature and there's Nurture. Is there also some X, some further contributor to what we are? There's Chance. Luck. This extra ingredient is important but doesn't have to come from the quantum bowels of our atoms or from some distant star. It is all around us in the causeless coin-flipping of our noisy world, automatically filling in the gaps of specification left unfixed by our genes, and unfixed by salient causes in our environment.
Yes, genes are important for understanding our behavior. Incredibly important - after all, they code for every protein pertinent to brain function, endocrinology, etc., etc. But the regulation of genes is often more interesting than the genes themselves, and it's the environment that regulates genes.
The regulation of genes is often more interesting than the genes themselves, and it's the environment that regulates genes.
We will create life from inanimate compounds, and we will find life in space. But the life that should more immediately interest us lies between these extremes, in the middle range we all inhabit between our genes and our stars.
We're taught to solely blame our luck-of-the-draw genes for our health issues, rather than our daily habits, dietary choices, and interplay with the environment that surrounds us.
Realizing the ways in which we humans may have been inadvertently changing our genes for millennia provides a way for us to begin to think about the inevitable genetic revolution in medicine that is going to allow us to advertently change our genes over centuries and even decades.
Many people assume the diseases that kill us are pre-programmed into our genes. High blood pressure by 55, heart attacks at 60, maybe cancer at 70, and so on... But for most of the leading causes of death, our genes usually account for only 10-20 per cent of risk.
Contrary to what we've been taught, genes do not determine physical and character traits on their own. Rather, they interact with the environment in a dynamic, ongoing process that produces and continually refines an individual
In our evolutionary narratives, the organism itself often seems to play a passive role: a powerless victim, almost, of changes to its environment or mutations in its genes.
All the work on heritability was never based on looking at genes; it was based on the similarity between identical twins or between parents and children. Now that geneticists can look at genes, they can't find genes that account for more than 10 percent of the variation in any human trait.
Epigenetics doesn't change the genetic code, it changes how that's read. Perfectly normal genes can result in cancer or death. Vice-versa, in the right environment, mutant genes won't be expressed. Genes are equivalent to blueprints; epigenetics is the contractor. They change the assembly, the structure.
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