A Quote by Gerald Fischbach
In autism there is just genes in part more or less of a probability that you will have the disorder, and that is where interactions with the environment are key.
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Everyone recognises that genes are part of the story but autism isn't 100% genetic. Even if you have identical twins who share all their genes, you can find that one has autism and one doesn't. That means that there must be some non-genetic factors.
I think one of the problems with the definition of autism is we keep expanding it. It started as "early infantile autism", and then it became "autism", and now it's "autism spectrum disorder". I'm not opposed to that from the standpoint of trying to broaden our vistas, and so forth. But from a research point of view, the term autism is lost in specificity.
Genes are not simple triggers. No one is hardwired to commit murder or any other crime. Our actions are always the result of stupendously complex gene-environment interactions, and environment is likely to remain the more important influence by far.
From a scientific standpoint, Aspergers and autism are one syndrome. Aspergers is part of the autism spectrum, not a separate disorder.
The study of how substances alter gene expression is part of the field of epigenetics. Some chemical exposures appear to turn on and turn off genes in ways that disregulate cell growth and predispose for cancer. From this perspective, our genes are less the command-and-control masters of our cells and more like the keys of piano, with the environment as the hands of the pianist.
The regulation of genes is often more interesting than the genes themselves, and it's the environment that regulates genes.
I did not mean to suggest that autism could be traced to Neanderthal genes. The point is that some genes that have been implicated in autism changed pretty significantly between the time Neanderthal line and human line split.
Our experience in fooling around with the genes of mice has taught us that many of the traits that interest us are not definite products of specific mutations but emergent phenomena arising from extremely complex interactions between genes, environment, and life experience.
Yes, genes are important for understanding our behavior. Incredibly important - after all, they code for every protein pertinent to brain function, endocrinology, etc., etc. But the regulation of genes is often more interesting than the genes themselves, and it's the environment that regulates genes.
Complex organisms cannot be construed as the sum of their genes, nor do genes alone build particular items of anatomy or behavior by themselves. Most genes influence several aspects of anatomy and behavior as they operate through complex interactions with other genes and their products, and with environmental factors both within and outside the developing organism. We fall into a deep error, not just a harmful oversimplification, when we speak of genes "for" particular items of anatomy or behavior.
As a scientist leading a funding agency for autism research, I think of autism as a neurodevelopmental disorder.
The key to a better life: Complain less, appreciate more. Whine less, laugh more. Talk less, listen more. Want less, give more. Hate less, love more. Scold less, praise more. Fear less, hope more.
A person's health isn't generally a reflection of genes, but how their environment is influencing them. Genes are the direct cause of less than 1pc of diseases: 99pc is how we respond to the world.
We know cancer is caused ultimately via a link between the environment and genes. There are genes inside cells that tell cells to grow and the same genes tell cells to stop growing. When you deregulate these genes, you unleash cancer. Now, what disrupts these genes? Mutations.
The great paradox of determinism and free will, which has held the attention of the wisest of philosophers and psychologists for generations, can be phrased in more biological terms as follows: If our genes are inherited, and our environment is a train of physical events set in motion before we were born, how can there be a truly independent agent within the brain? The agent itself is created by the interaction of the genes and the environment. It would appear that our freedom is only a self delusion.
I think that if I could do any sort of research of autism that I wanted to do, at this point I would take a sample of classic, early infantile autism persons and compare them with what I call "classic late onset autism", individuals. I think we will find that the cause of those youngsters with autism who have autism from birth is probably different than those who have late onset autism.
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