A Quote by Isaac Newton

The hypothesis of matter's being at first evenly spread through the heavens is, in my opinion, inconsistent with the hypothesis of innate gravity without a supernatural power to reconcile them, and therefore, it infers a deity.
Hypothesis is a toll which can cause trouble if not used properly. We must be ready to abandon our hypothesis as soon as it is shown to be inconsistent with the facts.
If the hypothesis of evolution is true, living matter must have arisen from non-living matter; for by the hypothesis the condition of the globe was at one time such, that living matter could not have existed in it, life being entirely incompatible with the gaseous state.
[Coining phrase "null hypothesis"] In relation to any experiment we may speak of this hypothesis as the "null hypothesis," and it should be noted that the null hypothesis is never proved or established, but is possibly disproved, in the course of experimentation. Every experiment may be said to exist only in order to give the facts a chance of disproving the null hypothesis.
Mr. Darwin's hypothesis is not, so far as I am aware, inconsistent with any known biological fact; on the contrary, if admitted, the facts of Development, of Comparative Anatomy, of Geographical Distribution, and of Palaeontology, become connected together, and exhibit a meaning such as they never possessed before; and I, for one, am fully convinced that if not precisely true, that hypothesis is as near an approximation to the truth as, for example, the Copernican hypothesis was to the true theory of the planetary motions.
If we consistently act on the optimistic hypothesis, this hypothesis will tend to be realised; whilst by acting on the pessimistic hypothesis we can keep ourselves for ever in the pit of want.
The scientific discovery appears first as the hypothesis of an analogy; and science tends to become independent of the hypothesis.
The first objection to Darwinism is that it is only a guess and was never anything more. It is called a "hypothesis," but the word "hypothesis," though euphonious, dignified and high-sounding, is merely a scientific synonym for the old-fashioned word "guess." If Darwin had advanced his views as a guess they would not have survived for a year, but they have floated for half a century, buoyed up by the inflated word "hypothesis." When it is understood that "hypothesis" means "guess," people will inspect it more carefully before accepting it.
But I should be very sorry if an interpretation founded on a most conjectural scientific hypothesis were to get fastened to the text in Genesis... The rate of change of scientific hypothesis is naturally much more rapid than that of Biblical interpretations, so that if an interpretation is founded on such an hypothesis, it may help to keep the hypothesis above ground long after it ought to be buried and forgotten.
However the machine would permit us to test the hypothesis for any special value of n. We could carry out such tests for a sequence of consecutive values n=2,3,.. up to, say, n=100. If the result of at least one test were negative, the hypothesis would prove to be false; otherwise our confidence in the hypothesis would increase, and we should feel encouraged to attempt establishing the hypothesis, instead of trying to construct a counterexample.
The hypothesis of the supernatural and/or a supreme being is vague, unfounded, and inapplicable in any practical fashion
Tormented by conflicting feelings, I appealed to reason ; and it is reason which, amid so many dogmatic contradictions, now forces the hypothesis upon me. A priori dogmatism, applying itself to God, has proved fruitless: who knows whither the hypothesis, in its turn, will lead us? I will explain therefore how, studying in the silence of my heart, and far from every human consideration, the mystery of social revolutions, God, the great unknown, has become for me an hypothesis, I mean a necessary dialectical tool.
There is no logical impossibility in the hypothesis that the world sprang into being five minutes ago, exactly as it then was, with a population that "remembered" a wholly unreal past. There is no logically necessary connection between events at different times; therefore nothing that is happening now or will happen in the future can disprove the hypothesis that the world began five minutes ago.
Newton supposed that all matter attracted other matter inversely according to the square of the distance; and the hypothesis was found to account for the whole movements of the heavenly bodies; which all became verifications of what Newton supposed to be the law of the solar system. Adopt the hypothesis that Jesus was what He is represented, and the whole of the books and the history becomes a verification.
Current organisms have a higher probability of sharing a single code if the common ancestry hypothesis is true than they'd have if the hypothesis of separate ancestry were true. That is, the simpler hypothesis has the higher likelihood in the technical sense of "likelihood" used in statistics.
One finds the truth by making a hypothesis and comparing observations with the hypothesis.
This hypothesis (Parallel hypothesis) would not destroy itself at all easily.
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