A Quote by Isaac Newton

If anyone offers conjectures about the truth of things from the mere possibility of hypotheses, I do not see by what stipulation anything certain can be determined in any science, since one or another set of hypotheses may always be devised which will appear to supply new difficulties.
Given any rule, however "fundamental" or "necessary" for science, there are always circumstances when it is advisable not only to ignore the rule, but to adopt its opposite. For example, there are circumstances when it is advisable to introduce, elaborate and defend ad hoc hypotheses, or hypotheses which contradict well-established and generally accepted experimental results, or hypotheses whose content is smaller than the content of the existing and empirically adequate alternative, or self-inconsistent hypotheses, and so on.
Certainly it is permitted to anyone to put forward whatever hypotheses he wishes, and to develop the logical consequences contained in those hypotheses. But in order that this work merit the name of Geometry, it is necessary that these hypotheses or postulates express the result of the more simple and elementary observations of physical figures.
So far as hypotheses are concerned, let no one expect anything certain from astronomy, which cannot furnish it, lest he accept as the truth ideas conceived for another purpose, and depart from this study a greater fool than when he entered it.
In real science a hypothesis can never be proved true...A science which confines itself to correlating phenomena can never learn anything about the reality underlying the phenomena, while a science which goes further than this and introduces hypotheses about reality, can never acquire certain knowledge of a positive kind about reality; in whatever way we proceed, this is forever denied us.
True science is never speculative; it employs hypotheses as suggesting points for inquiry, but it never adopts the hypotheses as though they were demonstrated propositions.
Are not all Hypotheses erroneous, in which Light is supposed to consist in Pression or Motion, propagated through a fluid Medium? For in all these Hypotheses the Phaenomena of Light have been hitherto explain'd by supposing that they arise from new Modifications of the Rays; which is an erroneous Supposition.
The hypotheses which we accept ought to explain phenomena which we have observed. But they ought to do more than this; our hypotheses ought to foretell phenomena which have not yet been observed; ... because if the rule prevails, it includes all cases; and will determine them all, if we can only calculate its real consequences. Hence it will predict the results of new combinations, as well as explain the appearances which have occurred in old ones. And that it does this with certainty and correctness, is one mode in which the hypothesis is to be verified as right and useful.
The growth of our knowledge is the result of a process closely resembling what Darwin called 'natural selection'; that is, the natural selection of hypotheses: our knowledge consists, at every moment, of those hypotheses which have shown their (comparative) fitness by surviving so far in their struggle for existence, a competitive struggle which eliminates those hypotheses which are unfit.
We shall do better to abandon the whole attempt to learn the truthunless we can trust to the human mind's having such a powerof guessing right that before very many hypotheses shall have been tried, intelligent guessing may be expected to lead us to one which will support all tests, leaving the vast majority of possible hypotheses unexamined.
All science is based on models, and every scientific model comprises three distinct stages: statement of well-defined hypotheses; deduction of all the consequences of these hypotheses, and nothing but these consequences; confrontation of these consequences with observed data.
The best and safest way of philosophising seems to be, first to enquire diligently into the properties of things, and to establish those properties by experiences [experiments] and then to proceed slowly to hypotheses for the explanation of them. For hypotheses should be employed only in explaining the properties of things, but not assumed in determining them; unless so far as they may furnish experiments.
For it is the duty of an astronomer to compose the history of the celestial motions or hypotheses about them. Since he cannot in any certain way attain to the true causes, he will adopt whatever suppositions enable the motions to be computed correctly from the principles of geometry for the future as well as for the past.
When I was a teenager, science meshed with my developing ideals - such as the challenge to authority that was central to punk rock. In science, anyone from any walk of life could make a discovery that would overturn prevailing hypotheses. And that was a cause for celebration among scientists.
The past slips from our grasp. It leaves us only scattered things. The bond that united them eludes us. Our imagination usually fills in the void by making use of preconceived theories...Archaeology, then, does not supply us with certitudes, but rather with vague hypotheses. And in the shade of these hypotheses some artists are content to dream, considering them less as scientific facts than as sources of inspiration.
The purpose of scientific method is to select a single truth from among many hypothetical truths. That, more than anything else, is what science is all about. But historically science has done exactly the opposite. Through multiplication upon multiplication of facts, information, theories and hypotheses, it is science itself that is leading mankind from single absolute truths to multiple indeterminate, relative ones.
I am myself an empiric in natural philosophy, suffering my faith to go no further than my facts. I am pleased, however, to see the efforts of hypothetical speculation, because by the collisions of different hypotheses, truth may be elicited and science advanced in the end.
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