A Quote by Jacques Dubochet
We see chemistry, how the atoms are arranged in the molecules, how the disease changes the arrangement. Perhaps we will find which drug disentangles the aggregates that make a brain senile. Many of us are interested in such things.
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Chemistry is the science of atoms. Elaborating on Democritus' idea, chemists learn how atoms stick or don't stick together, thus forming molecules.
Are the atoms of the dextroacid (tartaric) grouped in the spirals of a right-hand helix or situated at the angles of an irregular tetrahedron, or arranged in such or such particular unsymmetrical fashion? We are unable to reply to these questions. But there can be no reason for doubting that the grouping of the atoms has an unsymmetrical arrangement with a non-superimposable image. It is not less certain that the atoms of the laevo-acid realize precisely an unsymmetrical arrangement of the inverse of the above.
The Universal mind is not only intelligence, but it is substance, and this substance is the attractive force which brings electrons together by the law of attraction so they form atoms; the atoms in turn are brought together by the same law and form molecules; molecules take objective forms and so we find that the law is the creative force behind every manifestation, not only of atoms, but of worlds, of the universe, of everything of which the imagination can form any conception.
See the minutes, how they run,
How many make the hour full complete;
How many hours bring about the day;
How many days will finish up the year;
How many years a mortal man may live.
I became interested in structure when I was in graduate school. How is it that the brain perceives structure in a sometimes disorganized and chaotic world? How and why do we categorize things? Why can things be categorized in so many different ways, all of which can seem equally valid?
Quantum physics forms the foundation of chemistry, explaining how molecules are held together. It describes how real solids and materials behave and how electricity is conducted through them... It enabled the development of transistors, integrated circuits, lasers, LEDs, digital cameras and all the modern gadgetry that surrounds us.
I started my scientific work by putting forward a hypothesis on the arrangement of atoms in nitrogen-containing molecules.
Every effective drug provokes in the human body a sort of disease of its own, and the stronger the drug, the more characteristic, and the more marked and more violent the disease. We should imitate nature, which sometimes cures a chronic affliction with another supervening disease, and prescribe for the illness we wish to cure, especially if chronic, a drug with power to provoke another, artificial disease, as similar as possible, and the former disease will be cured: fight like with like.
The molecules that comprise our body are traceable to the crucibles of the centers of stars.These atoms and molecules are in us because, in fact, the universe is in us. And, we are not only figuratively, but literally, stardust.
We may, I believe, anticipate that the chemist of the future who is interested in the structure of proteins, nucleic acids, polysaccharides, and other complex substances with high molecular weight will come to rely upon a new structural chemistry, involving precise geometrical relationships among the atoms in the molecules and the rigorous application of the new structural principles, and that great progress will be made, through this technique, in the attack, by chemical methods, on the problems of biology and medicine.
The actual atoms and molecules that make up my brain and body today are not the same ones that I was born with on September 8, 1954, a half-century ago this month.
I'll get rid of the drug problem. The first drug dealer will be publicly executed in front of everybody and all of the sudden the rest of the drug dealers are going to go "Uh oh!" Watch how fast the drug problem disappears. If you use drugs, you're addicted and you steal something, you'll get sent off to the outback and to work camps and all of the sudden no drug addicts. See how simple that is? So simple.
The question whether atoms exist or not... belongs rather to metaphysics. In chemistry we have only to decide whether the assumption of atoms is an hypothesis adapted to the explanation of chemical phenomena... whether a further development of the atomic hypothesis promises to advance our knowledge of the mechanism of chemical phenomena... I rather expect that we shall some day find, for what we now call atoms, a mathematico-mechanical explanation, which will render an account of atomic weight, of atomicity, and of numerous other properties of the so-called atoms.
We are trying to find drugs, small molecules, that people could take to make them disease-resistant, more youthful and healthy. Eventually we will find them.
Most of us lead far more meaningful lives than we know. Often finding meaning is not about doing things differently; it is about seeing familiar things in new ways. When we find new eyes, the unsuspected blessing in work we have done for many years may take us completely by surprise. We can see life in many ways: with the eye, with the mind, with the intuition. But perhaps it is only those who speak the language of meaning, who have remembered how to see with the heart, that life is ever deeply known or served.
I suspect that many of us, if given the chance to make one person in our lives love us more, would have no trouble in choosing where to point a finger. We are all needy, all vulnerable, all terrified that perhaps that person has an excellent reason to withhold affection. We shape our purposes to make ourselves worthy and often do not see until much later how it was love-or perhaps the lack of it-that both picked us up and dropped us off at crossroads.
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