A Quote by Jacques Dubochet

The world is large, very large. My head is small, quite small. There is no way I can put the world in my head. Nevertheless, I have been trying to elaborate some kind of representation.
Do not be afraid of large patterns, if properly designed they are more restful to the eye than small ones: on the whole, a pattern where the structure is large and the details much broken up is the most useful...very small rooms, as well as very large ones, look better ornamented with large patterns.
From building a fire one can learn something about artistic composition. If you use only small kindling and large logs, the fire will quickly eat up the small pieces but will not become strong enough to attack the large ones. You must supply a scale of sizes from the smallest to the largest. The human eye also will not make its way into a painting or building unless a continuum of shapes leads from the small to the large, from the large to the small.
Practice by drawing things large, as if equal in representation and reality. In small drawings every large weakness is easily hidden; in the large, the smallest weakness is easily seen.
Clothing sizes are weird, they go: small, medium, large and then extra large, extra extra large, extra extra extra large. Something happened at large, they just gave up. They were like, 'I'm not doing any more adjectives; you just keep putting extras on there.' We could do better than that: small, medium, large, whoa, easy, slow down, stop it, interesting, American.
And when this grand canvas, our life, is finished, may the world in some small or large way be a better place.
It is certain that there may be extraordinary mental activity with an extremely small absolute mass of nervous matter: thus the wonderfully diversified instincts, mental powers, and affections of ants are notorious, yet their cerebral ganglia are not so large as the quarter of a small pin's head. Under this point of view, the brain of an ant is one of the most marvelous atoms of matter in the world, perhaps more so than the brain of a man.
A large retinue upon a small income, like a large cascade upon a small stream, tends to discover its tenuity.
The basic idea of Western science is that you don't have to take into account the falling of a leaf on some planet in another galaxy when you're trying to account for the motion of a billiard ball on a pool table on earth. Very small influences can be neglected. There's a convergence in the way things work, and arbitrarily small influences don't blow up to have arbitrarily large effects.
Obstacles will look large or small to you according to whether you are large or small.
Nevertheless, the number of farmers, small as well as large, who are adopting the new seeds and new technology is increasing very rapidly, and the increase in numbers during the past three years has been phenomenal.
Most persons think that a state in order to be happy ought to be large; but even if they are right, they have no idea of what is a large and what a small state.... To the size of states there is a limit, as there is to other things, plants, animals, implements; for none of these retain their natural power when they are too large or too small, but they either wholly lose their nature, or are spoiled.
I've directed our defense community headed by our great general now Secretary [James] Mattis, he's over there now working very hard to submit a plan for the defeat of ISIS, a group that celebrates the murder and torture of innocent people in large sections of the world, used to be a small group, now it's in large sections of the world.
I live in a very small house, but my windows look out on a very large world.
I grew up in a small town with a very small library. But the books in the library opened a large place in my heart. It is the place where stories live. And those stories have been informing my days, comforting my nights, and extending possibilities ever since. If that library had not been there, if the books - such as they were - had not been free, my world would be poor, even today.
The spirit in the body is like wine in a glass; when it spills, it seeps into air and earth and light….It’s a mistake to think it’s the small things we control and not the large, it’s the other way around! We can’t stop the small accident, the tiny detail that conspires into fate: the extra moment you run back for something forgotten, a moment that saves you from an accident – or causes one. But we can assert the largest order, the large human values daily, the only order large enough to see.
Miracles are a retelling in small letters of the very same story which is written across the whole world in letters too large for some of us to see.
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