A Quote by James Rothman
One of the major lessons in all of biochemistry, cell biology and molecular medicine is that when proteins operate at the sub cellular level, they behave in a certain way as if they're mechanical machinery.
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Evolution, cell biology, biochemistry, and developmental biology have made extraordinary progress in the last hundred years - much of it since I was weaned on schoolboy biology in the 1930s. Most striking of all is the sudden eruption of molecular biology starting in the 1950s.
Biology is far from understanding exactly how a single cell develops into a baby, but research suggests that human development can ultimately be explained in terms of biochemistry and molecular biology. Most scientists would make a similar statement about evolution.
By then, I was making the slow transition from classical biochemistry to molecular biology and becoming increasingly preoccupied with how genes act and how proteins are made.
If belief in evolution is a requirement to be a real scientist, it’s interesting to consider a quote from Dr. Marc Kirschner, founding chair of the Department of Systems Biology at Harvard Medical School:
“In fact, over the last 100 years, almost all of biology has proceeded independent of evolution, except evolutionary biology itself. Molecular biology, biochemistry, physiology, have not taken evolution into account at all.
Molecular biology is essentially the practice of biochemistry without a license.
A renaissance in cellular biology has recently revealed the molecular mechanisms by which thoughts and perceptions directly influence gene activity and cell behavior...Energy psychology, through its ability to rapidly identify and reprogram limiting misconceptions, represents the most powerful and effective process to enhance physical and emotional well being.
I think it's going to be amazing to see how the world of microbiology, molecular and cellular biology, and human physiology is massively changed by microgravity.
A paradigm shift is the best a scientist can hope for. Whenever I smell an opportunity like that, I go after it. You have a new discovery that something's working in a different way than you thought. And this is particularly true in molecular and cell biology, which is structural biology and has the least potential for controversy and partisanship among the biological scientists. You're dealing with a concrete object that's either there or not there.
Basically, the body does have a vast amount of inbuilt anti-ageing machinery; it's just not 100% comprehensive, so it allows a small number of different types of molecular and cellular damage to happen and accumulate.
There's that effect that is very physical, very down there at the synaptic level, which really means microscopic cellular level, but also molecular level, because all of those structures are operating on an electrochemical basis and so the changes there are very important.
During the decade following the discovery of the double-helical structure of DNA, the problem of translation - namely, how genetic information is used to synthesize proteins - was a central topic in molecular biology.
It could be that at some earlier time, somewhere in the universe, a civilization evolved by probably some kind of Darwinian means to a very, very high level of technology- and designed a form of life that they seeded onto perhaps this planet. And I suppose it's possible that you might find evidence for that if you look at the details of biochemistry, molecular biology, you might find a signature of some sort of designer.
We may, I believe, anticipate that the chemist of the future who is interested in the structure of proteins, nucleic acids, polysaccharides, and other complex substances with high molecular weight will come to rely upon a new structural chemistry, involving precise geometrical relationships among the atoms in the molecules and the rigorous application of the new structural principles, and that great progress will be made, through this technique, in the attack, by chemical methods, on the problems of biology and medicine.
If I say [electrons] behave like particles I give the wrong impression; also if I say they behave like waves. They behave in their own inimitable way, which technically could be called a quantum mechanical way. They behave in a way that is like nothing that you have seen before.
The second half of the 20th century was a golden age of molecular biology, and it was one of the golden ages of the history of science. Molecular biology was so successful and made such a powerful alliance with the medical scientists that the two together just flourished. And they continue to flourish.
I chose biochemistry as my major and graduated after 4 years with an Honours degree in Biochemistry. During that time, I had come to love biochemistry research, although I was just getting my feet wet in laboratory research.
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