A Quote by Jennifer Doudna
There's already a lot of active research going on using the Crispr technology to fix diseases like Duchenne muscular dystrophy or cystic fibrosis or Huntington's disease. They're all diseases that have known genetic causes, and we now have the technology that can repair those mutations to provide, we hope, patients with a normal life.
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My goals over the decade include to develop new drugs to treat intractable diseases by using iPS cell technology and to conduct clinical trials using it on a few patients with Parkinson's diseases, diabetes or blood diseases.
A scenario is, everyone takes gene therapy - not just curing rare diseases like cystic fibrosis, but diseases that everyone has, like aging.
We cannot idealize technology. Technology is only and always the reflection of our own imagination, and its uses must be conditioned by our own values. Technology can help cure diseases, but we can prevent a lot of diseases by old-fashioned changes in behavior.
My own area of expertise is the genetics of human disease. I was fortunate to be part of the team that found the genes for cystic fibrosis, and Huntington's disease and neurofibromatosis.
Muscular dystrophy ... was never seen until Duchenne described it in the 1850s. By 1860, after his original description, many hundreds of cases had been recognised and described, so much so that Charcot said: 'How is it that a disease so common, so widespread, and so recognisable at a glance - a disease which has doubtless always existed - how is it that it is recognised only now? Why did we need M. Duchenne to open our eyes?'
While there is no cure, cystic fibrosis is so close to being a livable disease. There is a lot of hope.
The ultimate goal is to have a pill that can prevent or reverse all diseases of aging. The major diseases that I'd like to tackle are heart disease, diabetes, Alzheimer's and cancer. I want to reduce those diseases by 10 percent.
For many years there have been treatments available which are successful and usually NOT harmful for diseases, such as AIDS, cancer, cystic fibrosis, diabetes, organ regeneration and other diseases. One by one these treatments and their creators or proponents have been targeted by the FDA, which I call the "office of orthodoxy enforcement," illegally using just powers derived from the consent of governed. These forms of tyranny are always accompanied by multi agency intrusions or harassment, confiscation of private medical files, censorship of written materials and threats or prosecution.
We start with an economic approach. We look at what are the greatest causes of death in the developing world, and what causes the largest amount of disability, which would prevent you from getting a job. A lot of those deaths start with diseases, diseases we don't get in such a great number in the United States.
It's known that stress gives rise to disease. It's also known that many diseases, especially stress-related diseases, can be cured by placebos - pills that have no medicinal effect, but people think they do, and so they do.
The research center at VCU has really done a great job of welcoming us in and we've contributed a lot of money to them because they do a lot of the research for cystic fibrosis.
There are many different causes of the scarring. Viruses are common. Hepatitis B, hepatitis C, what we call autoimmune diseases where the body attacks the liver itself such as primary biliary cirrhosis is an autoimmune disease; sclerosing cholangitis is an autoimmune disease; and so those diseases where the liver is being destroyed by either the virus or an autoimmune disease, it can only scar, and why it doesn't regenerate has to do with the fact that there is this ongoing scar tissue that blocks that regeneration.
I really do believe that America has this weight problem - obesity issues - and we have all these diseases that we get - heart disease, cancer, diabetes, autoimmune diseases - that are primarily lifestyle diseases.
It is my hope that the number of stem cell lines available for federally-funded research will be expanded so that the government can continue to participate in this vital research and provide hope to the millions of Americans with diseases that might be cured.
There are several patients - there are thousands of patients, tens of thousands of patients, that carry either a stimulator in the brain or in the periphery, in the inner ear, to restore neurological functions or to control diseases like Parkinson's disease.
Psychiatrists look for twisted molecules and defective genes as the causes of schizophrenia, because schizophrenia is the name of a disease. If Christianity or Communism were called diseases, would they then look for the chemical and genetic "causes" of these "conditions"?
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