A Quote by Liz Parrish
Work by Maria Blasco, Calvin Harley, Michael Fossel, Woodring Wright and Shay and Ronald Depinho in particular are of interest but there are literally thousands of articles relating to telomerase, telomeres and the biology behind it.
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I agree Maria Blasco has achieved amazing things with telomerase induction and we are hopeful this will translate to the human model.
For me, arguably the story of telomeres and telomerase began thousands of years ago, in the cornfields of the Maya highlands of Central America.
This enzyme, called telomerase, slows the rate at which telomeres degrade, and research indicates that healthy people with longer telomeres have less risk of developing the common illnesses of aging - like heart disease, diabetes, and cancer, which are three big killers today.
What I found out on Christmas Day 1984, through biochemical evidence, was that telomeres could be lengthened by the enzyme we called telomerase, which keeps the telomeres from wearing down. After I found that out, I went home and put on Bruce Springsteen's 'Born in the USA,' which was just out, and I danced and danced and danced.
In 1978, Elizabeth Blackburn, working with Joe Gall, identified the DNA sequence of telomeres. Every time a cell divides, it gets shorter. But telomeres usually don't. So there must be something happening to the telomeres to keep their length in equilibrium.
When you bring telomerase RNA levels down by using a mechanism that targets the RNA for destruction, the cells which were running on very high telomerase levels are now running on a lean diet of telomerase.
Telomeres are the ends of our chromosomes that control how long we live. As telomeres become shorter, then cells age and die more quickly. In simple terms, as your telomeres get shorter, your life gets shorter.
We believe that such a significant increase in longevity is due to the protective effect against cancer produced by caloric restriction - incidences fall by 40 percent if we compare them with the mice that produce more telomerase and have a normal diet - and, added to the presence of longer telomeres, this makes the mice live longer and better.
You can't compare us, but I do think that Calvin Klein influenced his way of working. Calvin created this whole aesthetic with imagery - the whole sex thing. I can see that Calvin influence on his work. What Calvin has created is untouchable. My legacy, whatever it is I'm doing here, is miniscule compared to what he has done. It's just like an update deal.
I have a tweet that said, 'I want to be a Calvin Klein model,' and that was in 2011. And then I modeled for Calvin Klein. And then I had a tweet like, 'I wonder what it's like to be in front of thousands of fans,' and I've been in front of thousands of fans.
Cancer cells have had so many other things go wrong with them, genetic, non-genetic changes, that those cells, one of the things they then get selected for is that they have lots of telomerase because now the telomeres in those cells get maintained.
I think that Walter De Maria's Lightning Field, Michael Heizer's City, and Charles Ross's work in Star Axis New Mexico , all three will last for a millennium.
Within a few years the name 'Maria Sharapova' will be a brand as universally recognized as Calvin Klein, BMW and Rolex.
I worked with Michael Black and Michael Showalter on their show 'Michael and Michael Have Issues.' We did some stuff on that, but it ended up not getting picked up for a second season. There will be more stuff, but not right now. Michael Showalter and I are literally next-door neighbors. We see quite a lot of each other.
[Calvin, who has the chicken pox, calls Susie on the telephone.] Susie: Hello? Calvin: Hi, Susie! It's me, Calvin! I was wondering if you'd like to come over and play. Susie: Why, sure! Boy, I don't think you've ever invited me to... Calvin's Mom: Calvin, what are you doing? Calvin: Nothing, Mom. Go away. Calvin's Mom: You're contagious! You can't have anyone over to play! Calvin: Shhhh! Shhhh! You'll spoil the whole thing! I was going to trick Susie into catching... HEY! OW! LET GO! Susie: [Hanging up the phone] Any chance of getting transferred, Dad?
I got to train with some of the best and have critics like Oscar de la Renta and Calvin Klein. As a student under Calvin Klein, my project was to make a coat, and then years later, I was hired at Calvin, by Calvin, to design coats for him. It came full circle!
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