A Quote by Martin Chalfie
Trying to understand fundamental processes that take place as organisms develop and how their various cells interact with one another - one can see what happens with those cells by asking questions about the fundamentals of biology.
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Bacteria are single-celled organisms. Bacteria are the model organisms for everything that we know in higher organisms. There are 10 times more bacterial cells in you or on you than human cells.
In nerve-free multicellular organisms, the relationships of the cells to each other can only be of a chemical nature. In multicellular organisms with nerve systems, the nerve cells only represent cells like any others, but they have extensions suited to the purpose which they serve, namely the nerves.
Both in Britain and America, huge publicity has been given to stem cells, particularly embryonic stem cells, and the potential they offer. Of course, the study of stem cells is one of the most exciting areas in biology, but I think it is unlikely that embryonic stem cells are likely to be useful in healthcare for a long time.
Once the principle is there, that cells have the same genes, my own personal belief is that we will, in the end, understand everything about how cells actually work.
The task of neural science is to explain behaviour in terms of the activities of the brain. How does the brain marshall its millions of individual nerve cells to produce behaviour, and how are these cells influenced by the environment...? The last frontier of the biological sciences – their ultimate challenge – is to understand the biological basis of consciousness and the mental processes by which we perceive, act, learn, and remember.
Single cells analyze thousands of stimuli from the microenvironment they inhabit. The more awareness an organism has of its environment, the better its chances for survival. When cells band together they increase their awareness exponentially. Division of labor among the cells in the community offers an additional survival advantage. The efficiency it enables more cells to live on less. Evolution is based on an instructive, cooperative interaction among organisms and their environment enables life forms to survive and evolve in a dynamic world.
Well, there are two kinds of stem cells: adult stem cells, which you can get from any part of a grown body, and embryonic stem cells. These are the inner- core of days-old embryos that can develop into any kind of cell.
Man, like other organisms, is so perfectly coordinated that he may easily forget, whether awake or asleep, that he is a colony of cells in action, and that it is the cells which achieve, through him, what he has the illusion of accomplishing himself.
Conversational intelligence is hard-wired into every single human-being's cells. It's the way the cells engage with each other. Believe it or not, cells talk to each other. The immune system talks to the cells.
Most of our brain cells are glial cells, once thought to be mere support cells, but now understood as having a critical role in brain function. Glial cells in the human brain are markedly different from glial cells in other brains, suggesting that they may be important in the evolution of brain function.
One of the first papers I wrote at the University of Wisconsin, in 1977, was on stem cells. I realized that if I changed the environment that these cells were in, I could turn the cells into bone, and if I changed the environment a bit more, they would form fat cells.
There's really no such thing as the agony of dying. I'm quite sure that pain is shut off at the moment of death. You see, something happens when the body knows it's about to go. Peptide hormones are released by cells in the hypothalamus and pituitary gland. Endorphins. They attach themselves to the cells responsible for feeling pain.
The brain is really hard to see. The whole thing is very large - the human brain is several pounds in weight - but the connections between brain cells, known as synapses, are really tiny. They're nanoscale in dimension. So if you want to see how the cells of the brain are connected in networks, you have to see those connections, those synapses.
IPS cells can become a powerful tool to develop new drugs to cure intractable diseases because they can be made from patients' somatic cells.
When we talk about stem cells, we are actually talking about a complicated series of things, including adult stem cells which are largely cells devoted to replacing individual tissues like blood elements or liver or even the brain.
Cancer cells have had so many other things go wrong with them, genetic, non-genetic changes, that those cells, one of the things they then get selected for is that they have lots of telomerase because now the telomeres in those cells get maintained.
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