A Quote by Norman Mailer
Madness is locked beneath. It goes into tissues, is swallowed by the cells. The cells go mad. Cancer is their flag. Cancer is thegrowth of madness denied.
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You've got to get away from the idea cancer is a disease to be cured. It's not a disease really. The cancer cell is your own body, your own cells, just misbehaving and going a bit wrong, and you don't have to cure cancer. You don't have to get rid of all those cells. Most people have cancer cells swirling around inside them all the time and mostly they don't do any harm, so what we want to do is prevent the cancer from gaining control. We just want to keep it in check for long enough that people die of something else.
We know cancer is caused ultimately via a link between the environment and genes. There are genes inside cells that tell cells to grow and the same genes tell cells to stop growing. When you deregulate these genes, you unleash cancer. Now, what disrupts these genes? Mutations.
Cancer essentially lives in us and becomes activated at some point, and then cells begin to psychotically divide. Initially, the cancer cell looks like other cells and the body invites it in.
I was working with stem cells as part of a NASA programme. We realised that the science of stem-cell proliferation was also fundamental to cancer cells when cancer enters the phase of metastasis.
If you inhale a millionth of a gram of plutonium, the surrounding cells receive a very, very high dose. Most die within that area, because it's an alpha emitter. The cells on the periphery remain viable. They mutate, and the regulatory genes are damaged. Years later, that person develops cancer. Now, that's true for radioactive iodine, that goes to the thyroid; cesium-137, that goes to the brain and muscles; strontium-90 goes to bone, causing bone cancer and leukemia.
When are we going to say cancer is cured? I'm not sure when that will happen, if that will happen because cancer is a very slippery disease and it involves a vast number of cells in the body and those cells are continually mutating.
The most dangerous cancer cells are actually the ones that are more like stem cells, which have this ability to produce themselves over and over again. More and more cancer biologists say stem-cell-like cells in cancers are the most dangerous.
Cancer is the growth of madness denied.
Cancer cells have had so many other things go wrong with them, genetic, non-genetic changes, that those cells, one of the things they then get selected for is that they have lots of telomerase because now the telomeres in those cells get maintained.
Cancer is really a DNA disease... We have these certain genes that prevent our cells from growing out of control at the expense of the body. And it's a pretty good, robust system. But if a couple of these genes fail, then that's when cancer starts, and cells start growing out of control.
Cancer vaccines are in the future. And they could be very effective. Checkpoint blockade, which is acting your immune system to recognize those cancer cells and kill them is another very promising approach and there have been some checkpoint blockade drugs out in the market now that will release the brake on T lymphocytes, the T lymphocyte is your major killer of tumor cells.
It turns out that the very genes that turn on in cancer cells perform vital functions in normal cells. In other words, the very genes that allow our embryos to grow or our brains to grow, our bodies to grow, if you mutate them, if you distort them, then you unleash cancer.
Broccoli is incredible. It can prevent DNA damage and metastatic cancer spread; activate defences against pathogens and pollutants; help to prevent lymphoma; boost the enzymes that detox your liver; target breast cancer stem cells; and reduce the risk of prostate cancer progression.
When we talk about stem cells, we are actually talking about a complicated series of things, including adult stem cells which are largely cells devoted to replacing individual tissues like blood elements or liver or even the brain.
A fundamental premise in cancer therapy is trying to identify how the metabolism of cancer cells differs from normal tissue. When differences are identified, it often paves the way for treatments that will disrupt the cancer's metabolism while sparing normal tissue.
I think the big danger of madness is not madness itself, but the habit of madness. What I discovered during the time I spent in the asylum is that I could choose madness and spend my whole life without working, doing nothing, pretending to be mad. It was a very strong temptation.
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