A Quote by Peter Medawar

It is a common failing-and one that I have myself suffered from-to fall in love with a hypothesis and to be unwilling to take no for an answer. A love affair with a pet hypothesis can waste years of precious time. There is very often no finally decisive yes, though quite often there can be a decisive no.
[Coining phrase "null hypothesis"] In relation to any experiment we may speak of this hypothesis as the "null hypothesis," and it should be noted that the null hypothesis is never proved or established, but is possibly disproved, in the course of experimentation. Every experiment may be said to exist only in order to give the facts a chance of disproving the null hypothesis.
But I should be very sorry if an interpretation founded on a most conjectural scientific hypothesis were to get fastened to the text in Genesis... The rate of change of scientific hypothesis is naturally much more rapid than that of Biblical interpretations, so that if an interpretation is founded on such an hypothesis, it may help to keep the hypothesis above ground long after it ought to be buried and forgotten.
If we consistently act on the optimistic hypothesis, this hypothesis will tend to be realised; whilst by acting on the pessimistic hypothesis we can keep ourselves for ever in the pit of want.
Current organisms have a higher probability of sharing a single code if the common ancestry hypothesis is true than they'd have if the hypothesis of separate ancestry were true. That is, the simpler hypothesis has the higher likelihood in the technical sense of "likelihood" used in statistics.
The first objection to Darwinism is that it is only a guess and was never anything more. It is called a "hypothesis," but the word "hypothesis," though euphonious, dignified and high-sounding, is merely a scientific synonym for the old-fashioned word "guess." If Darwin had advanced his views as a guess they would not have survived for a year, but they have floated for half a century, buoyed up by the inflated word "hypothesis." When it is understood that "hypothesis" means "guess," people will inspect it more carefully before accepting it.
My writing is an answer to the partisans of the many and it returns their attack with interest, with a view to showing that the hypothesis of the many, if examined sufficiently in detail, leads to even more ridiculous results than the hypothesis of the One.
When I was younger, I'd get very empirical with myself. "I have a hypothesis about myself. I'll put myself in a situation, see what happens, then I'll draw a conclusion based on the empirical evidence. Hypothesis: I can play basketball." So I'd try. "Conclusion: I cannot play basketball."
It is absolutely essential that one should be neutral and not fall in love with the hypothesis.
Do you fall in love often?" Yes often. With a view, with a book, with a dog, a cat, with numbers, with friends, with complete strangers, with nothing at all.
However the machine would permit us to test the hypothesis for any special value of n. We could carry out such tests for a sequence of consecutive values n=2,3,.. up to, say, n=100. If the result of at least one test were negative, the hypothesis would prove to be false; otherwise our confidence in the hypothesis would increase, and we should feel encouraged to attempt establishing the hypothesis, instead of trying to construct a counterexample.
A hypothesis or theory is clear, decisive, and positive, but it is believed by no one but the man who created it. Experimental findings, on the other hand, are messy, inexact things, which are believed by everyone except the man who did that work.
Cartier-Bresson has said that photography seizes a 'decisive moment', that's true except that it shouldn't be taken too narrowly...does my picture of a cobweb in the rain represent a decisive moment? The exposure time was probably three or four minutes. That's a pretty long moment. I would say the decisive moment in that case was the moment in which I saw this thing and decided I wanted to photograph it.
Throughout the day I often ask myself, Could I fall asleep right now? and the answer is always a resounding yes.
World War II was a decisive time in our history and June 6, 1944, marked the decisive moment of the war.
This constitution we designate by the word genotype. The word is entirely independent of any hypothesis; it is fact, not hypothesis that different zygotes arising by fertilisation can thereby have different qualities, that, even under quite similar conditions of life, phenotypically diverse individuals can develop.
The scientific discovery appears first as the hypothesis of an analogy; and science tends to become independent of the hypothesis.
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