A Quote by Ronald Fisher

[Coining phrase "null hypothesis"] In relation to any experiment we may speak of this hypothesis as the "null hypothesis," and it should be noted that the null hypothesis is never proved or established, but is possibly disproved, in the course of experimentation. Every experiment may be said to exist only in order to give the facts a chance of disproving the null hypothesis.
It appears, then, to be a condition of a genuinely scientific hypothesis, that it be not destined always to remain an hypothesis, but be certain to be either proved or disproved by.. .comparison with observed facts.
But I should be very sorry if an interpretation founded on a most conjectural scientific hypothesis were to get fastened to the text in Genesis... The rate of change of scientific hypothesis is naturally much more rapid than that of Biblical interpretations, so that if an interpretation is founded on such an hypothesis, it may help to keep the hypothesis above ground long after it ought to be buried and forgotten.
What used to be called prejudice is now called a null hypothesis.
If we consistently act on the optimistic hypothesis, this hypothesis will tend to be realised; whilst by acting on the pessimistic hypothesis we can keep ourselves for ever in the pit of want.
However the machine would permit us to test the hypothesis for any special value of n. We could carry out such tests for a sequence of consecutive values n=2,3,.. up to, say, n=100. If the result of at least one test were negative, the hypothesis would prove to be false; otherwise our confidence in the hypothesis would increase, and we should feel encouraged to attempt establishing the hypothesis, instead of trying to construct a counterexample.
It is possible to express the laws of thermodynamics in the form of independent principles , deduced by induction from the facts of observation and experiment, without reference to any hypothesis as to the occult molecular operations with which the sensible phenomena may be conceived to be connected; and that course will be followed in the body of the present treatise. But, in giving a brief historical sketch of the progress of thermodynamics, the progress of the hypothesis of thermic molecular motions cannot be wholly separated from that of the purely inductive theory.
Mr. Darwin's hypothesis is not, so far as I am aware, inconsistent with any known biological fact; on the contrary, if admitted, the facts of Development, of Comparative Anatomy, of Geographical Distribution, and of Palaeontology, become connected together, and exhibit a meaning such as they never possessed before; and I, for one, am fully convinced that if not precisely true, that hypothesis is as near an approximation to the truth as, for example, the Copernican hypothesis was to the true theory of the planetary motions.
The first objection to Darwinism is that it is only a guess and was never anything more. It is called a "hypothesis," but the word "hypothesis," though euphonious, dignified and high-sounding, is merely a scientific synonym for the old-fashioned word "guess." If Darwin had advanced his views as a guess they would not have survived for a year, but they have floated for half a century, buoyed up by the inflated word "hypothesis." When it is understood that "hypothesis" means "guess," people will inspect it more carefully before accepting it.
Hypothesis is a toll which can cause trouble if not used properly. We must be ready to abandon our hypothesis as soon as it is shown to be inconsistent with the facts.
This, it may be said, is no more than a hypothesis, but it satisfies the conditions of a legitimate hypothesis, by postulating the operation of no unknown or uncertain cause, but only of that force of precedent which in all times has been so strong to keep alive religious forms of which the original meaning is lost.
Current organisms have a higher probability of sharing a single code if the common ancestry hypothesis is true than they'd have if the hypothesis of separate ancestry were true. That is, the simpler hypothesis has the higher likelihood in the technical sense of "likelihood" used in statistics.
The scientific discovery appears first as the hypothesis of an analogy; and science tends to become independent of the hypothesis.
One finds the truth by making a hypothesis and comparing observations with the hypothesis.
This hypothesis (Parallel hypothesis) would not destroy itself at all easily.
Tormented by conflicting feelings, I appealed to reason ; and it is reason which, amid so many dogmatic contradictions, now forces the hypothesis upon me. A priori dogmatism, applying itself to God, has proved fruitless: who knows whither the hypothesis, in its turn, will lead us? I will explain therefore how, studying in the silence of my heart, and far from every human consideration, the mystery of social revolutions, God, the great unknown, has become for me an hypothesis, I mean a necessary dialectical tool.
A hypothesis is empirical or scientific only if it can be tested by experience. A hypothesis or theory which cannot be, at least in principle, falsified by empirical observations and experiments does not belong to the realm of science.
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