A Quote by Ronan O'Rahilly

Although life is a continuous process, fertilization is a critical landmark because, under ordinary circumstances, a new, genetically distinct human organism is thereby formed.... The combination of 23 chromosomes present in each pronucleus results in 46 chromosomes in the zygote. Thus the diploid number is restored and the embryonic genome is formed. The embryo now exists as a genetic unity.
The egg of every species of animal or plant carries a definite number of bodies called chromosomes. The sperm carries the same number. Consequently, when the sperm unites with the egg, the fertilized egg will contain the double number of chromosomes.
Telomeres are the protective caps at the ends of chromosomes in cells. Chromosomes carry the genetic information. Telomeres are buffers. They are like the tips of shoelaces. If you lose the tips, the ends start fraying.
For it is not cell nuclei, not even individual chromosomes, but certain parts of certain chromosomes from certain cells that must be isolated and collected in enormous quantities for analysis; that would be the precondition for placing the chemist in such a position as would allow him to analyse [the hereditary material] more minutely than [can] the morphologists ... For the morphology of the nucleus has reference at the very least to the gearing of the clock, but at best the chemistry of the nucleus refers only to the metal from which the gears are formed.
It is often said that all the conditions for the first production of a living organism are now present, which could ever have been present. But if (and oh! what a big if!) we could conceive in some warm little pond, with all sorts of ammonia and phosphoric salts, light, heat, electricity, &c., present, that a proteine compound was chemically formed ready to undergo stillmore complex changes, at the present day such matter would be instantly devoured or absorbed, which would not have been the case before living creatures were formed.
A zygote is the beginning of a new human being (i.e., an embryo).
Each part of our genome is unique. We would not be alive if there was not a single mathematical solution for our chromosomes. We would just be scrambled goo.
...congenital killers and criminals are possessed of not one but two Y chromosomes, bearing a double dose, as it were, of genetically undesirable maleness.
The idea that cancer genes are sitting inside each and every one of our chromosomes, just waiting to be corrupted or inactivated and thereby unleashing cancer, is, of course, one of the seminal ideas of oncology.
Except for certain moments - when cells are dividing, for instance - chromosomes don't form compact, countable bodies inside cells. Instead, they unravel and flop about, which makes counting chromosomes a bit like counting strands of ramen in a bowl.
This fertilized ovum, known as a zygote, is a large diploid cell that is the beginning, or primordium, of a human being.
Although the teachers or the students are not the same, the person in charge of education is being formed or re-formed as he/she teaches, and the person who is being taught forms him/herself in the process. ...There is, in fact, no teaching without learning.
Every mutation through a new combination of genetic factors that provides the organism with a new opportunity for coming to terms with the conditions of its environment signifies no more and no less than that new information about this environment has got into that organic system. Adaptation is essentially a cognitive process.
Except for the rare cases of plastid inheritance, the inheritance of all known cooacters can be sufficiently accounted for by the presence of genes in the chromosomes. In a word the cytoplasm may be ignored genetically.
We have long been seeking a different kind of evolutionary process and have now found one; namely, the change within the pattern of the chromosomes. ... The neo-Darwinian theory of the geneticists is no longer tenable.
The question is, are there useful things that we can do with the results of a genome sequence that would bring benefit? And the answer is, today, should the majority of people go and have their genome sequenced? Probably not. But are there particular circumstances in which genome sequencing is really helpful? Yes, there are.
If we think of our chromosomes - they carry our genetic material - as being like shoelaces, I work on the plastic tips at the end that protect them.
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