A Quote by Sam Kean
Mutations can arise anywhere in the genome, in gene DNA and noncoding DNA alike. But mutations to genes have bigger consequences: They can disable proteins and kill a creature.
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Somewhere in our DNA must lie the key mutation (or, more probably, mutations) that set us apart—the mutations that make us the sort of creature that could wipe out its nearest relative, then dig up its bones and reassemble its genome.
A DNA sequence for the genome of bacteriophage ?X174 of approximately 5,375 nucleotides has been determined using the rapid and simple 'plus and minus' method. The sequence identifies many of the features responsible for the production of the proteins of the nine known genes of the organism, including initiation and termination sites for the proteins and RNAs. Two pairs of genes are coded by the same region of DNA using different reading frames.
In the late 1970s, when I was a professor at Caltech, I pioneered four instruments for analyzing genes and proteins that revolutionized modern biology - and one of these, the automated DNA sequencer, enabled the Human Genome Project.
Most organisms have loads of junk DNA - less pejoratively, noncoding DNA - cluttering their cells.
All human beings are, in fact, born with dozens of mutations their parents lacked, and a few of those mutations could well be lethal if we didn't have two copies of every gene, so one can pick up the slack if the other malfunctions.
Junk DNA - or, as scientists call it nowadays, noncoding DNA - remains a mystery: No one knows how much of it is essential for life.
The messages that DNA molecules contain are all but eternal when seen against the time scale of individual lifetimes. The lifetimes of DNA messages give or take a few mutations are measured in units ranging from millions of years to hundreds of millions of years; or, in other words, ranging from 10,000 individual lifetimes to a trillion individual lifetimes. Each individual organism should be seen as a temporary vehicle, in which DNA messages spend a tiny fraction of their geological lifetimes.
Most mutations involve typos: Something bumps a cell's elbow as it's copying DNA, and the wrong letter appears in a triplet - CAG becomes CCG.
With DNA, you have to be able to tell which genes are turned on or off. Current DNA sequencing cannot do that. The next generation of DNA sequencing needs to be able to do this. If somebody invents this, then we can start to very precisely identify cures for diseases.
We add that it would be all too easy to object that mutations have no evolutionary effect because they are eliminated by natural selection. Lethal mutations (the worst kind) are effectively eliminated, but others persist as alleles. ...Mutants are present within every population, from bacteria to man. There can be no doubt about it. But for the evolutionist, the essential lies elsewhere: in the fact that mutations do not coincide with evolution.
Just like mutations to DNA in biological organisms allow for evolution through natural selection, forking lets us run multiple experiments in parallel where the strongest versions survive.
We know cancer is caused ultimately via a link between the environment and genes. There are genes inside cells that tell cells to grow and the same genes tell cells to stop growing. When you deregulate these genes, you unleash cancer. Now, what disrupts these genes? Mutations.
It once seemed that the most profound feats stemming from DNA-based science would spring from our ability to read and detect genes, which we call the science of genomics. But the real opportunities lie in our ability to write DNA, to synthesize new gene sequences and insert them into organisms, resulting in brand-new biological functions.
Our science and advisory board think that nuclear lamin dysfunction is a side-effect of DNA damage and mutations, rather than the cause. We are currently trying to mend nuclear dysfunction using Human Telomerase reverse transcriptase.
We are machines built by DNA whose purpose is to make more copies of the same DNA. ... This is exactly what we are for. We are machines for propagating DNA, and the propagation of DNA is a self-sustaining process. It is every living object's sole reason for living.
First of all, many human diseases are influenced by, if not caused by mutations in genes.
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