A Quote by Sam Kean

All human beings are, in fact, born with dozens of mutations their parents lacked, and a few of those mutations could well be lethal if we didn't have two copies of every gene, so one can pick up the slack if the other malfunctions.
We add that it would be all too easy to object that mutations have no evolutionary effect because they are eliminated by natural selection. Lethal mutations (the worst kind) are effectively eliminated, but others persist as alleles. ...Mutants are present within every population, from bacteria to man. There can be no doubt about it. But for the evolutionist, the essential lies elsewhere: in the fact that mutations do not coincide with evolution.
Mutations can arise anywhere in the genome, in gene DNA and noncoding DNA alike. But mutations to genes have bigger consequences: They can disable proteins and kill a creature.
When you get sick with the flu you get infected with flu viruses and they make lots of new flu viruses, but those new viruses are not exact copies of the old ones. They have mutations in them. A lot of those mutations are harmful.
Somewhere in our DNA must lie the key mutation (or, more probably, mutations) that set us apart—the mutations that make us the sort of creature that could wipe out its nearest relative, then dig up its bones and reassemble its genome.
My idea right from the beginning, I guess, was to dismantle the immune system one gene at a time so we could track the mutations that cause problems.
In the meantime, the educated public continues to believe that Darwin has provided all the relevant answers by the magic formula of random mutations plus natural selection -quite unaware of the fact that random mutations turned out to be irrelevant and natural selection tautology.
Whereas recessive traits require two bad copies of a gene to become noticeable, a dominant trait expresses itself no matter what the other copy does. A benign example of dominance: If you inherit one gene for sticky wet earwax and one gene for dry earwax, the sticky earwax gene wins out every time.
You would think that UV just causes mutations, but it doesn't; you need a gene to be active for it.
You would think that UV just causes mutations, but it doesn't, you need a gene to be active for it.
After observing mutations in fruit flies for many years, Professes Goldschmidt fell into despair. The changes, he lamented, were so hopelessly micro [insignificant] that if a thousand mutations were combined in one specimen, there would still be no new species.
In agriculture, people have taken wild plants that can't be eaten by people - and turned them into wonderful food sources. And that's because genomes can change, and people working with plants have picked mutations. Mutations are nothing more than genetic changes.
Every batch of sperm represents an opportunity for genetic typos - called de novo mutations - to be passed on. A 20-year-old man and woman will each pass on about 20 de novo mutations to a baby they conceive. By the time the couple is 40, a woman's total has remained at 20, while a man's has jumped to 65 - and it keeps climbing from there.
Clearly, we are a species that is well connected to other species. Whether or not we evolve from them, we are certainly very closely related to them. A series of mutations could change us into all kinds of intermediate species. Whether or not those intermediate species are provably in the past, they could easily be in our future.
Fundamentalism in most of its forms is the active creation of antibodies to some threatening [god] virus. As long as threatening religions or mutations [heresies] are present, fundamentalism will churn out antibodies to keep the population under control and prevent mutations from getting out of hand.
It is probably fair to estimate the frequency of a majority of mutations, in higher organisms, between one in ten thousand and one in a million per gene per generation.
A company like Adobe, there are dozens of different teams that are using Slack. Each of those elected to use Slack independently.
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