A Quote by Sandra Steingraber
The study of how substances alter gene expression is part of the field of epigenetics. Some chemical exposures appear to turn on and turn off genes in ways that disregulate cell growth and predispose for cancer. From this perspective, our genes are less the command-and-control masters of our cells and more like the keys of piano, with the environment as the hands of the pianist.
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We know cancer is caused ultimately via a link between the environment and genes. There are genes inside cells that tell cells to grow and the same genes tell cells to stop growing. When you deregulate these genes, you unleash cancer. Now, what disrupts these genes? Mutations.
Epigenetics doesn't change the genetic code, it changes how that's read. Perfectly normal genes can result in cancer or death. Vice-versa, in the right environment, mutant genes won't be expressed. Genes are equivalent to blueprints; epigenetics is the contractor. They change the assembly, the structure.
It turns out that the very genes that turn on in cancer cells perform vital functions in normal cells. In other words, the very genes that allow our embryos to grow or our brains to grow, our bodies to grow, if you mutate them, if you distort them, then you unleash cancer.
Cancer is really a DNA disease... We have these certain genes that prevent our cells from growing out of control at the expense of the body. And it's a pretty good, robust system. But if a couple of these genes fail, then that's when cancer starts, and cells start growing out of control.
Each of our cells is a living entity, and the main thing that influences them is our blood. If I open my eyes in the morning and my beautiful partner is in front of me, my perception causes a release of oxytocin, dopamine, growth hormones - all of which encourage the growth and health of my cells. But if I see a saber tooth tiger, I'm going to release stress hormones which change the cells to a protection mode. People need to realize that their thoughts are more primary than their genes, because the environment, which is influenced by our thoughts, controls the genes.
Nearly every one of the genes that turns out to be a key player in cancer has a vital role in the normal physiology of an organism. The genes that enable our brains and blood cells to develop are implicated in cancer.
The great paradox of determinism and free will, which has held the attention of the wisest of philosophers and psychologists for generations, can be phrased in more biological terms as follows: If our genes are inherited, and our environment is a train of physical events set in motion before we were born, how can there be a truly independent agent within the brain? The agent itself is created by the interaction of the genes and the environment. It would appear that our freedom is only a self delusion.
Yes, genes are important for understanding our behavior. Incredibly important - after all, they code for every protein pertinent to brain function, endocrinology, etc., etc. But the regulation of genes is often more interesting than the genes themselves, and it's the environment that regulates genes.
Isn't it true that whatever isn't determined by our genes must be determined by our environment? What else is there? There's Nature and there's Nurture. Is there also some X, some further contributor to what we are? There's Chance. Luck. This extra ingredient is important but doesn't have to come from the quantum bowels of our atoms or from some distant star. It is all around us in the causeless coin-flipping of our noisy world, automatically filling in the gaps of specification left unfixed by our genes, and unfixed by salient causes in our environment.
A cancer is not simply a lung cancer. It doesn't simply have a certain kind of appearance under the microscope or a certain behavior, but it also has a set of changes in the genes or in the molecules that modify gene behavior that allows us to categorize cancers in ways that is very useful in thinking about new ways to control cancer by prevention and treatment.
We all have genes that come from our ancestors that aren't used - they're not turned on. So we actually carry ancient genes with us. If you could figure out how to turn those on, you could resurrect ancient characteristics from our ancestors.
The regulation of genes is often more interesting than the genes themselves, and it's the environment that regulates genes.
A person's health isn't generally a reflection of genes, but how their environment is influencing them. Genes are the direct cause of less than 1pc of diseases: 99pc is how we respond to the world.
While nobody has identified any gene for religion, there are certainly some candidate genes that may influence human personality and confer a tendency to religious feelings. Some of the genes likely to be involved are those which control levels of different chemicals called neurotransmitters in the brain.
Individuals are not stable things, they are fleeting. Chromosomes too are shuffled into oblivion, like hands of cards soon after they are dealt. But the cards themselves survive the shuffling. The cards are the genes. The genes are not destroyed by crossing-over, they merely change partners and march on. Of course they march on. That is their business. They are the replicators and we are their survival machines. When we have served our purpose we are cast aside. But genes are denizens of geological time: genes are forever.
When you're coming into a company and, you know, have to do a transformation, what you really want to do is look at the company and say, 'Okay, here are the parts that the company does well. How do we get those genes to hyper-express? The genes that are getting in the way, how do you turn those off?'
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