A Quote by Siddhartha Mukherjee
Down to their innate molecular core, cancer cells are hyperactive, survival-endowed, scrappy, fecund, inventive copies of ourselves.
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Cancer's life is a recapitulation of the body's life, its existence a pathological mirror of our own. Susan Sontag warned against overburdening an illness with metaphors. But this is not a metaphor. Down to their innate molecular core, cancer cells are hyperactive, survival-endowed, scrappy, fecund, inventive copies of ourselves.
You've got to get away from the idea cancer is a disease to be cured. It's not a disease really. The cancer cell is your own body, your own cells, just misbehaving and going a bit wrong, and you don't have to cure cancer. You don't have to get rid of all those cells. Most people have cancer cells swirling around inside them all the time and mostly they don't do any harm, so what we want to do is prevent the cancer from gaining control. We just want to keep it in check for long enough that people die of something else.
Intelligence is a valuable thing, but it is not usually the key to survival. Sheer fecundity ... usually counts. The intelligent gorilla doesn't do as well as the less intelligent but more-fecund rat, which doesn't do as well as the still-less-intelligent but still-more-fecund cockroach, which doesn't do as well as the minimally-intelligent but maximally-fecund bacterium.
We know cancer is caused ultimately via a link between the environment and genes. There are genes inside cells that tell cells to grow and the same genes tell cells to stop growing. When you deregulate these genes, you unleash cancer. Now, what disrupts these genes? Mutations.
Cancer essentially lives in us and becomes activated at some point, and then cells begin to psychotically divide. Initially, the cancer cell looks like other cells and the body invites it in.
Cancer cells come pre-programmed to execute a well-defined cascade of changes, seemingly designed to facilitate both their enhanced survival and their dissemination through the bloodstream. There is even an air of conspiracy in the way that tumours use chemical signals to create cancer-friendly niches in remote organs.
Madness is locked beneath. It goes into tissues, is swallowed by the cells. The cells go mad. Cancer is their flag. Cancer is thegrowth of madness denied.
I was working with stem cells as part of a NASA programme. We realised that the science of stem-cell proliferation was also fundamental to cancer cells when cancer enters the phase of metastasis.
Single cells analyze thousands of stimuli from the microenvironment they inhabit. The more awareness an organism has of its environment, the better its chances for survival. When cells band together they increase their awareness exponentially. Division of labor among the cells in the community offers an additional survival advantage. The efficiency it enables more cells to live on less. Evolution is based on an instructive, cooperative interaction among organisms and their environment enables life forms to survive and evolve in a dynamic world.
When are we going to say cancer is cured? I'm not sure when that will happen, if that will happen because cancer is a very slippery disease and it involves a vast number of cells in the body and those cells are continually mutating.
The most dangerous cancer cells are actually the ones that are more like stem cells, which have this ability to produce themselves over and over again. More and more cancer biologists say stem-cell-like cells in cancers are the most dangerous.
The core of original sin, then is LOT - Lack of Trust. Or, it could be considered an innate inability to adequately value ourselves. Label it a 'negative self-image,' but do not say that the central core of the human soul is wickedness. ... positive Christianity does not hold to human depravity, but to human inability.
Molecular biology has shown that even the simplest of all living systems on the earth today, bacterial cells, are exceedingly complex objects. Although the tiniest bacterial cells are incredibly small, weighing less than 10-12 gms, each is in effect a veritable micro-miniaturized factory containing thousands of exquisitely designed pieces of intricate molecular machinery, made up altogether of one hundred thousand million atoms, far more complicated than any machine built by man and absolutely without parallel in the nonliving world.
Cancer is really a DNA disease... We have these certain genes that prevent our cells from growing out of control at the expense of the body. And it's a pretty good, robust system. But if a couple of these genes fail, then that's when cancer starts, and cells start growing out of control.
Well, there are two kinds of stem cells: adult stem cells, which you can get from any part of a grown body, and embryonic stem cells. These are the inner- core of days-old embryos that can develop into any kind of cell.
Cancer cells have had so many other things go wrong with them, genetic, non-genetic changes, that those cells, one of the things they then get selected for is that they have lots of telomerase because now the telomeres in those cells get maintained.
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