A Quote by Siddhartha Mukherjee
We know cancer is caused ultimately via a link between the environment and genes. There are genes inside cells that tell cells to grow and the same genes tell cells to stop growing. When you deregulate these genes, you unleash cancer. Now, what disrupts these genes? Mutations.
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It turns out that the very genes that turn on in cancer cells perform vital functions in normal cells. In other words, the very genes that allow our embryos to grow or our brains to grow, our bodies to grow, if you mutate them, if you distort them, then you unleash cancer.
Cancer is really a DNA disease... We have these certain genes that prevent our cells from growing out of control at the expense of the body. And it's a pretty good, robust system. But if a couple of these genes fail, then that's when cancer starts, and cells start growing out of control.
Nearly every one of the genes that turns out to be a key player in cancer has a vital role in the normal physiology of an organism. The genes that enable our brains and blood cells to develop are implicated in cancer.
The study of how substances alter gene expression is part of the field of epigenetics. Some chemical exposures appear to turn on and turn off genes in ways that disregulate cell growth and predispose for cancer. From this perspective, our genes are less the command-and-control masters of our cells and more like the keys of piano, with the environment as the hands of the pianist.
Epigenetics doesn't change the genetic code, it changes how that's read. Perfectly normal genes can result in cancer or death. Vice-versa, in the right environment, mutant genes won't be expressed. Genes are equivalent to blueprints; epigenetics is the contractor. They change the assembly, the structure.
The regulation of genes is often more interesting than the genes themselves, and it's the environment that regulates genes.
Yes, genes are important for understanding our behavior. Incredibly important - after all, they code for every protein pertinent to brain function, endocrinology, etc., etc. But the regulation of genes is often more interesting than the genes themselves, and it's the environment that regulates genes.
Each of our cells is a living entity, and the main thing that influences them is our blood. If I open my eyes in the morning and my beautiful partner is in front of me, my perception causes a release of oxytocin, dopamine, growth hormones - all of which encourage the growth and health of my cells. But if I see a saber tooth tiger, I'm going to release stress hormones which change the cells to a protection mode. People need to realize that their thoughts are more primary than their genes, because the environment, which is influenced by our thoughts, controls the genes.
Growth is kinda built into everyone's genes. It's built into management's genes, the salesman's genes, the investors' desires. People expect companies to grow.
Once the principle is there, that cells have the same genes, my own personal belief is that we will, in the end, understand everything about how cells actually work.
All the work on heritability was never based on looking at genes; it was based on the similarity between identical twins or between parents and children. Now that geneticists can look at genes, they can't find genes that account for more than 10 percent of the variation in any human trait.
If there's a seminal discovery in oncology in the last 20 years, it's that idea that cancer genes are often mutated versions of normal genes.
Cheetah genes cooperate with cheetah genes but not with camel genes, and vice versa. This is not because cheetah genes, even in the most poetic sense, see any virtue in the preservation of the cheetah species. They are not working to save the cheetah from extinction like some molecular World Wildlife Fund.
It's a very complex network of genes making products which go into the nucleus and turn on other genes. And, in fact, you find a continuing network of processes going on in a very complex way by which genes are subject to these continual adjustments, as you might say - the computer programmer deciding which genes ultimately will work.
People's genes can say a great deal about their health. There are genes that reveal an increased likelihood of getting cancer, heart disease or Alzheimer's.
If you inhale a millionth of a gram of plutonium, the surrounding cells receive a very, very high dose. Most die within that area, because it's an alpha emitter. The cells on the periphery remain viable. They mutate, and the regulatory genes are damaged. Years later, that person develops cancer. Now, that's true for radioactive iodine, that goes to the thyroid; cesium-137, that goes to the brain and muscles; strontium-90 goes to bone, causing bone cancer and leukemia.
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