A Quote by Venkatraman Ramakrishnan

I cannot imagine a more enjoyable place to work than in the Laboratory of Molecular Biology where I work. — © Venkatraman Ramakrishnan
I cannot imagine a more enjoyable place to work than in the Laboratory of Molecular Biology where I work.
I decided to pursue graduate study in molecular biology and was accepted by Professor Itaru Watanabe's laboratory at the Institute for Virus Research at the University of Kyoto, one of a few laboratories in Japan where U.S.-trained molecular biologists were actively engaged in research.
I decided that the University of Sussex in Brighton was a good place for this work because it had a strong tradition in bacterial molecular genetics and an excellent reputation in biology.
The second half of the 20th century was a golden age of molecular biology, and it was one of the golden ages of the history of science. Molecular biology was so successful and made such a powerful alliance with the medical scientists that the two together just flourished. And they continue to flourish.
Evolution, cell biology, biochemistry, and developmental biology have made extraordinary progress in the last hundred years - much of it since I was weaned on schoolboy biology in the 1930s. Most striking of all is the sudden eruption of molecular biology starting in the 1950s.
It does not seem to be true that work necessarily needs to be unpleasant. It may always have to be hard, or at least harder than doing nothing at all. But there is ample evidence that work can be enjoyable, and that indeed, it is often the most enjoyable part of life.
But while doing that I'd been following a variety of fields in science and technology, including the work in molecular biology, genetic engineering, and so forth.
It is now widely realized that nearly all the 'classical' problems of molecular biology have either been solved or will be solved in the next decade. The entry of large numbers of American and other biochemists into the field will ensure that all the chemical details of replication and transcription will be elucidated. Because of this, I have long felt that the future of molecular biology lies in the extension of research to other fields of biology, notably development and the nervous system.
My habit is to get real competitive and make racing probably more work than it is enjoyable, and I put a lot of pressure on myself, and I feel like there's pressure from the outside - it's probably not real, but it's something I imagine.
I began my thesis research at Harvard by working with a team in the laboratory of William N. Lipscomb, a Nobel chemistry Laureate, in 1976, on the structure of carboxypeptidase A. I did postdoctoral studies with David Blow at the MRC lab of Molecular Biology in Cambridge studying chymotrypsin.
Much of my work in biology has been driven by my early training in chemistry. When studying a new chemical compound, the first and most important thing is to determine its detailed molecular structure.
If belief in evolution is a requirement to be a real scientist, it’s interesting to consider a quote from Dr. Marc Kirschner, founding chair of the Department of Systems Biology at Harvard Medical School: “In fact, over the last 100 years, almost all of biology has proceeded independent of evolution, except evolutionary biology itself. Molecular biology, biochemistry, physiology, have not taken evolution into account at all.
What's been gratifying is to live long enough to see molecular biology and evolutionary biology growing toward each other and uniting in research efforts.
Posterity will one day laugh at the sublime foolishness of the modern materialistic philosophy. The more I study nature, the more I stand amazed at the work of the Creator. I pray while I am engaged at my work in the laboratory.
The moment I saw the model and heard about the complementing base pairs I realized that it was the key to understanding all the problems in biology we had found intractable - it was the birth of molecular biology.
Molecular biology has shown that even the simplest of all living systems on the earth today, bacterial cells, are exceedingly complex objects. Although the tiniest bacterial cells are incredibly small, weighing less than 10-12 gms, each is in effect a veritable micro-miniaturized factory containing thousands of exquisitely designed pieces of intricate molecular machinery, made up altogether of one hundred thousand million atoms, far more complicated than any machine built by man and absolutely without parallel in the nonliving world.
I went into science, ending up with a Ph.D. in cell biology, but along the way I found out that experimental science involves many hours and days and nights of laboratory work, which is a lot like washing dishes, only a little more challenging. I was too impatient, and maybe a little too sloppy, for it.
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