A Quote by Gene Wolfe

Science has so accustomed us to devising and accepting theories to account for the facts we observe, however fantastic, that our minds must begin their manufacture before we are aware of it.
Our minds are specifically adapted to developing certain theories, and we have a science if the theories that are available to our minds happen to be close to true. Well, there is no particular reason to suppose that the intersection of true theories and theories that are accessible to the mind is very large. It may not be very large.
It is clear that everybody interested in science must be interested in world 3 objects. A physical scientist, to start with, may be interested mainly in world 1 objects--say crystals and X-rays. But very soon he must realize how much depends on our interpretation of the facts, that is, on our theories, and so on world 3 objects. Similarly, a historian of science, or a philosopher interested in science must be largely a student of world 3 objects.
Science is much more than a body of knowledge. It is a way of thinking. This is central to its success. Science invites us to let the facts in, even when they don't conform to our preconceptions. It counsels us to carry alternative hypotheses in our heads and see which ones best match the facts. It urges on us a fine balance between no-holds-barred openness to new ideas, however heretical, and the most rigorous skeptical scrutiny of everything - new ideas and established wisdom.
We used to speak familiarly of an agent, now do more, who was accustomed to manufacture evidence, and to invent facts in his cases, or at least to alter the aspects of facts to such an extent that they might fairly be viewed as new.
In every enterprise ... the mind is always reasoning, and, even when we seem to act without a motive, an instinctive logic still directs the mind. Only we are not aware of it, because we begin by reasoning before we know or say that we are reasoning, just as we begin by speaking before we observe that we are speaking, and just as we begin by seeing and hearing before we know what we see or what we hear.
Facts and theories are different things, not rungs in a hierarchy of increasing certainty. Facts are the world's data. Theories are structures of ideas that explain and interpret facts. Facts do not go away while scientists debate rival theories for explaining them. Einstein's theory of gravitation replaced Newton's, but apples did not suspend themselves in mid-air pending the outcome.
It is a capital mistake to theorize before one has data. Insensibly one begins to twist facts to suit theories, instead of theories to suit facts.
We must remember that we do not observe nature as it actually exists, but nature exposed to our methods of perception. The theories determine what we can or cannot observe...Reality is an illusion, albeit a persistent one.
The existence of these patterns [fractals] challenges us to study forms that Euclid leaves aside as being formless, to investigate the morphology of the amorphous. Mathematicians have disdained this challenge, however, and have increasingly chosen to flee from nature by devising theories unrelated to anything we can see or feel.
Let us, my dear contemporaries, arise above such narrow prejudices. If wisdom be desirable on its own account, if virtue, to deserve the name, must be founded on knowledge, let us endeavour to strengthen our minds by reflection till our heads become a balance for our hearts.
Knowledge must be gained by ourselves. Mankind may supply us with facts; but the results, even if they agree with previous ones, must be the work of our own minds.
Generally speaking, geologists seem to have been much more intent on making little worlds of their own, than in examining the crust of that which they inhabit. It would be much more desirable that facts should be placed in the foreground and theories in the distance, than that theories should be brought forward at the expense of facts. So that, in after times, when the speculations of the present day shall have passed away, from a greater accumulation of information, the facts may be readily seized and converted to account.
Anthropology has reached that point of development where the careful investigation of facts shakes our firm belief in the far-reaching theories that have been built up. The complexity of each phenomenon dawns on our minds, and makes us desirous of proceeding more cautiously. Heretofore we have seen the features common to all human thought
Scientific theories need reconstruction every now and then. If they didn't need reconstruction they would be facts, not theories. The more facts we know, the less radical become the changes in our theories. Hence they are becoming more and more constant. But take the theory of gravitation; it has not been changed in four hundred years.
Progress is achieved by exchanging our theories for new ones which go further than the old, until we find one based on a larger number of facts. ... Theories are only hypotheses, verified by more or less numerous facts. Those verified by the most facts are the best, but even then they are never final, never to be absolutely believed.
Science fiction - and the correct shortcut is 'sf' - uses actual scientific facts or theories for the source ideas or framework of the story. It has some scientific content, however speculative. If it breaks a law of physics, it knows it's doing so and follows up the consequences. If it invents a society of aliens, it does so with some respect for and knowledge of the social sciences and what you might call social probabilities. And some of it is literarily self-aware enough to treat its metaphors as metaphors.
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