A Quote by John O'Keefe
It turns out that this part of the brain is one of the first areas that's attacked by Alzheimer's disease. So we can now use some of the basic understanding of this part of the brain to ask the simple question, 'What is going wrong with these special cells in the hippocampus at the very earliest stages?'
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One definitely wants to have a functioning hippocampus. It's all about learning and memory, the part blown out of the water by Alzheimer's disease. It's also the part that is most vulnerable to the effects of stress.
Most of our brain cells are glial cells, once thought to be mere support cells, but now understood as having a critical role in brain function. Glial cells in the human brain are markedly different from glial cells in other brains, suggesting that they may be important in the evolution of brain function.
I can't say when we will have a cure, but we now know through our findings how to ask the question of what is going wrong at the earliest stage of Alzheimer's.
Throughout our lifetimes, we are constantly regenerating new brain cells in the hippocampus, a process called neurogenesis. New stem cells are constantly being born in the hippocampus that ultimately differentiate into fully functional neurons.
Throughout our lifetimes we are constantly regenerating new brain cells in the hippocampus, a process called neurogenesis. New stem cells are constantly being born in the hippocampus that ultimately differentiate into fully functional neurons.
A long iron rod rocketed straight through the very forefront of Phineas Gage's brain. It's kind of an unusual part of the brain: you can suffer pretty severe injuries to it and often walk away from the injury. It's not a part of the brain that's necessarily vital for your biological self. But it is very important for personality.
The pace at which science has progressed has been too fast for human behaviour to adapt to it. As I said we are still apes. A part of our brain is still a paleo-brain and many of the reactions come from our fight or flight instinct. As long as this part of the brain can take over control the rational part of the brain (we will face these problems).
The brain is really hard to see. The whole thing is very large - the human brain is several pounds in weight - but the connections between brain cells, known as synapses, are really tiny. They're nanoscale in dimension. So if you want to see how the cells of the brain are connected in networks, you have to see those connections, those synapses.
A meticulous virtual copy of the human brain would enable basic research on brain cells and circuits or computer-based drug trials.
It turns out your conscious mind - the part you think of as you - is really the smallest part of what’s happening in your brain, and usually the last one in line to find out any information.
My lab looks at the ability of stress hormones to kill brain cells, and basically we are trying to understand on a molecular level how a neuron dies after a stroke, a seizure, Alzheimer's, brain aging, and what these stress hormones do to make it worse.
There's part of our brain that we shut off when we're in the studio. There's part of our brain that we turn on when we are out doing an interview or promoting something or waking up at six in the morning for hair and makeup.
We know that if memory is destroyed in one part of the brain, it can be sometimes re-created on a different part of the brain. And once we can unravel that amino chain of chemicals that is responsible for memory, I see no reason why we can't unlock it and, essentially, wipe out what's there.
There is also a particular area of sleep called slow-wave sleep. I immediately liked this idea. It turns out this part of sleep is where the brain basically gets into step with itself and gets into this one single phase of these relatively slow brain waves - around 10 Hz or so - and the whole brain 'fires all at once'. This is a brilliant bit of sleep where we consolidate memory and learning, and memory is one of my obsessions really.
I'm taking special treatments for the cancer in my brain and in my liver. Part of the liver was removed, and they did the treatment on four places in my brain with radiation. And now I'm taking a long-term medicine that stimulates my own immune system to fight against cancer.
I obviously love 'The Grey'; that was a pleasure to make. It was also very difficult. Listen, I love 'Smokin' Aces.' That was a lot of fun to make. Completely different part of your brain, I guess. Some would argue the part that they don't want you to use.
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