Prior to and during [John] Locke's time, it was difficult to determine where religion or church left off and government or state began. The powers of both were often combined. As a result, churches frequently used the force of the state to promote and enforce their interests and doctrines. This caused horrendous atrocities against Jews and heretics, as well as the European religious wars between Catholics and Protestants of the sixteenth and seventeenth centuries that resulted in the deaths of millions of people.